Dr Micheal Tsz Kin NG

Research Direction

• Therapeutic effects of stem cells, small molecules and herbal drugs on different ocular diseases
• Molecular genetics of different ocular diseases
• Human adult stem cell properties

Current Affiliations and Positions

• Adjunct Associate Professor, Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong
• Professor and Laboratory Director, Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, China

Representative Publications

1. Cen LP,# Ng TK,# Liang JJ, Zhuang X, Yao X, Yam GH, Chen H, Cheung HS, Zhang M, Pang CP. Human periodontal ligament-derived stem cells promote retinal ganglion cell survival and axon regeneration after optic nerve injury. Stem Cells 2018; 36: 844-855.
2. Yang Y, Xu C, Chen Y, Liang JJ, Xu Y, Chen SL, Huang S, Yang Q, Cen LP, Pang CP, Sun XH,* Ng TK.* Green tea extract ameliorates ischemia-induced retinal ganglion cell degeneration in rats. Oxid Med Cell Longev 2019; 2019: 8407206.
3. Tan S, Ng TK,* Xu Q, Yang M, Zhuang Y, Zhao J, Zhou H, Teng D, Wei S.* Vision improvement in severe acute isolated optic neuritis after plasma exchange treatment in Chinese population: a prospective case series study. Ther Adv Neurol Disord 2020; 13:1756286420947977.
4. Ng TK,# Yang Q,# Fortino VR, Lai NY, Carballosa CM, Greenberg JM, Choy KW, Pelaez D, Pang CP, Cheung HS. MicroRNA-132 directs human periodontal ligament-derived neural crest stem cell neural differentiation. J Tissue Eng Regen Med 2019; 13:12-24.
5. Liu J, Zhang R, Sun L, Zheng Y, Chen S, Chen SL, Xu Y, Pang CP, Zhang M,* Ng TK.* Genotype-phenotype correlation and interaction of 4q25, 15q14 and MIPEP variants with myopia in southern Chinese population. Brit J Ophthalmol 2019:bjophthalmol-2019-314782.
6. Wu Z, Huang C, Xu C, Xie L, Liang JJ, Liu L, Pang CP, Ng TK,* Zhang M.* Caveolin-1 regulates human trabecular meshwork cell adhesion, endocytosis and autophagy. J Cell Biochem 2019; 120:13382-13391.
7. Ng TK, Liang XY, Lu F, Liu DT, Yam GH, Ma L, Tam PO, Chen H, Cen LP, Chen LJ, Yang Z, Pang CP. Protective effects of an HTRA1 insertion-deletion variant against age-related macular degeneration in Chinese populations. Lab Invest 2017; 97:43-52.
8. Ng TK, Yung JS, Choy KW, Cao D, Leung CK, Cheung HS, Pang CP. Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature. Sci Rep 2015; 5:16429.
9. Ng TK,# Carballosa CM,# Pelaez D, Wong HK, Choy KW, Pang CP, Cheung HS. Nicotine alters microRNA expression and hinders human adult stem cell regenerative potential. Stem Cells Dev 2013; 22:781-790.
10. Ng TK, Yam GH, Chen WQ, Lee VY, Chen H, Chen LJ, Choy KW, Yang Z, Pang CP. Interactive expressions of HtrA1 and VEGF in human vitreous humors and fetal RPE cells. Invest Ophthalmol Vis Sci 2011; 52:3706-3712.