Prof PANG Chi Pui Calvin

Director

Prof THAM Chee Yung Clement

Faculty

Prof CHAN Sun On Hector

Faculty  

Prof LEUNG Kai Shun Christopher 梁啟信教授

Prof LEUNG Kai Shun Christopher

Faculty

Prof WANG Chi Chiu Ronald

Faculty

Prof NG Tsz Kin Michael

Faculty

Dr CHEN Li Jia Guy

Faculty  

Dr CHOY Kwong Wai Richard

Faculty

Dr CHEUNG Yim Lui Carol

Faculty

Prof CHU Wai Kit

Faculty

Dr CHEN Hao Yu

Faculty  

We are committed to research of eye diseases at the highest standard and offer unique opportunities in the study of eye diseases using state-of-the-art research technologies in our laboratories. Our basic science research involves studieson the etiology, molecular genetics, cell biology, histopathology, biochemistry, and therapeutic responses of various eye diseases. We have established a comprehensive research laboratory system with modern facilities:

1. Molecular Genetics and Genome Laboratories 
Automated sequencers, PCR and real-time PCR machines, DNA microarray scanner.

2. Cell Biology Laboratories
Laminar-flow clean bench, phase-contrast and fluorescence microscopes, ChemiDoc system.

3. Ocular Pathology Laboratory
Automated tissue processor and embedding center, crystat, and rotary microtome.

4. Analytical Laboratory
Sample processing facilities, HPLC, GCMS, and LCMSMS.

5. Animal Surgery and Animal Rooms
Surgical microscope, animal holding facilities.

6. Microscopy Laboratory
Fluorescence microcopy with imaging system, laser capture micro-dissection system.

We conduct research in the following fields with cross utilization of technologies on various disease entities :

Molecular genetics Genomic studies
Cell biology Stem cell biology
Toxicology studies Herbal medicine & pharmacology
Experimental animal models Epidemiology of eye diseases
Cataracts Cornea and external eye diseases
Refractive errors High myopia
Glaucoma Macular and retinal diseases
Ocular oncology: retinoblastoma Pediatric ophthalmology

Adipose-derived mesenchymal stem cell study

We will recruit systemic and local applications of autologous mesenchymal stem cells isolated from adipose tissue for various ocular disorders, including glaucoma, age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa as well as uveitis. We will evaluate the efficacy and safety of treatment by visual acuity and visual field examination, color vision test, slip-lamp biomicroscopy, Goldmann applanation tonometry, dilated funduscopy, gonioscopy, fluorescence angiography, optical coherent tomography, electroretinography (ERG) and multifocal ERG.

Ongoing Major Basic Science Research Programmes

We will recruit systemic and local applications of autologous mesenchymal stem cells isolated from adipose tissue for various ocular disorders, including glaucoma, age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa as well as uveitis. We will evaluate the efficacy and safety of treatment by visual acuity and visual field examination, color vision test, slip-lamp biomicroscopy, Goldmann applanation tonometry, dilated funduscopy, gonioscopy, fluorescence angiography, optical coherent tomography, electroretinography (ERG) and multifocal ERG.

Genomic investigations,gene mapping and molecular genetics of glaucoma, age-related macular degeneration, and high myopia. Genome wide association studies with SNP and microsatellite marker scanning, family linkage analysis, fine mapping, sequencing, cloning, and gene function analysis to identify disease loci and characterize disease genes. More than 50 families, 2,000 patients and 500 control subjects are involved in these studies.

Primary Open Angle Glaucoma(POAG). We were the first group to propose and confirm gain-of-function pathology in glaucoma caused by myocilin mutation. We have also identified 2 novel POAG chromosomal loci, GLCA1M and GLCA1N. We have recently identified a new susceptible gene for glaucoma and are currently characterizing its structure and properties. We participate in mapping CAV1 and CAV2 for POAG.