Simon KH SZETO

Research Programmes

1. International, multi-center, randomised controlled trial in macular hole surgery
2. Surgical management of submacular hemorrhage secondary to wet age related macular degeneration or polypoidal choroidal vasculopathy
3. The use of OCT biomarkers in predicting treatment outcome of refractory diabetic macular edema
4. The effect of next generation oral hypoglycemic agents on diabetic retinopathy and diabetic macular edema
5. The use of retinal imaging in the diagnosis and monitoring of cerebral small vessel disease

Accomplishments

1. Distinguished young fellow 2024, Hong Kong Academy of Medicine
2. Bronze medal, Asia-Pacific Vitreo-Retina Society Leadership Development Programme 2021-2022

Representative Publications:

#first author *corresponding author

1. Tsang KK, Hui VWK, Pang CMK, Tang Z, Yang D, Nguyen TX, Mohamed S, Lai TYY, Cheung CY, Szeto SKH*. SD-OCT-based biomarkers in predicting treatment outcomes of macular oedema secondary to retinal vein occlusion treated with anti-VEGF therapy. Acta Ophthalmol. 2025 Aug 4. doi: 10.1111/aos.17574. Epub ahead of print. PMID: 40757884.
2. Szeto SKH#*, Lam JTW, Yu AHY, Pang C, Lin TPH, Hui VWK, Tsang KK, Chan JCK, Chen LJ, Lai TYY, Mohamed S, Tsang CW. Macular Hole Closure by Internal Limiting Membrane Flap without Gas Tamponade versus Conventional Surgery: A Comparative Study. Ophthalmol Retina. 2025 Jun 13:S2468-6530(25)00276-3. doi: 10.1016/j.oret.2025.06.005. Epub ahead of print. PMID: 40518116.
3. Zhang S, Nguyen TX, Liu X, Szeto SKH, Cheung CY, Ran AR. Moving artificial intelligence development to deployment in ophthalmology: randomised controlled trials are warranted. Eye (Lond). 2025 Apr;39(5):816-818. doi: 10.1038/s41433-025-03708-2. Epub 2025 Feb 15. PMID: 39955374; PMCID: PMC11933475.
4. Tang Z, Yang D, Nguyen TX, Zhang S, Fang D, Chan VTT, Tham CC, Sohn EH, Tsang KK, Wong CYK, Hui VWK, Yu AHY, Lam JTW, Chan CKM, Lai TYY, Szeto SKH, Cheung CY. Relationship of OCT-Based Diabetic Retinal Neurodegeneration to the Development and Progression of Diabetic Retinopathy: A Cohort Study. Invest Ophthalmol Vis Sci. 2025 Feb 3;66(2):32. doi: 10.1167/iovs.66.2.32. PMID: 39932471; PMCID: PMC11817850.
5. Hui, Vivian W.K; Tsang, Chi Wai; Mohamed, Shaheeda; Fong, Angie H. C3; Lai, Timothy Y Y; Brelen, Marten; Szeto, Simon K.H*. Subretinal tissue plasminogen activator without vitrectomy for submacular hemorrhage displacement using Nano-vitreoretinal gateway device: A pilot report. Retinal Cases & Brief Reports ():10.1097/ICB.0000000000001699, November 12, 2024. | DOI: 10.1097/ICB.0000000000001699
6. Tang Z, Wang X, Ran AR, Yang D, Ling A, Yam JC, Zhang X, Szeto SKH, Chan J, Wong CYK, Hui VWK, Chan CKM, Wong TY, Cheng CY, Sabanayagam C, Tham YC, Liew G, Anantharaman G, Raman R, Cai Y, Che H, Luo L, Liu Q, Wong YL, Ngai AKY, Yuen VL, Kei N, Lai TYY, Chen H, Tham CC, Heng PA, Cheung CY. Deep learning-based image quality assessment for optical coherence tomography macular scans: a multicentre study. Br J Ophthalmol. 2024 Jul 20:bjo-2023-323871. doi: 10.1136/bjo-2023-323871. Epub ahead of print. PMID: 39033014.
7. Szeto SKH#*, Yu AHY, Tsang CW, Mohamed S, Chen LJ, Lai TYY. COMPLEX MACULAR HOLE CLOSURE BY TEMPORAL INTERNAL LIMITING MEMBRANE FLAP WITHOUT ENDOTAMPONADE. Retina. 2024 Nov 1;44(11):1915-1922. doi: 10.1097/IAE.0000000000004201. PMID: 39436300.
8. Trusong X, Meirui Jiang, Dawei Yang, An Ran Ran, Ziqi Tang, Shuyi Zhang, Xioyan Hu, Simon K.H. Szeto, Cherie Y.K. Wong, Vivian Hui, Ken Tsang, Carmen K.M. Chan,  Hunter Yuen, Victor T.T. Chan, Andrew Mak, Mary Ho, Wilson Yip, Alvin Young¹, Theodore Leng, Gavin Tan, Tien Yin Wong, Peng-Ann Heng, Clement C. Tham, Timothy Y. Y. Lai, Triet Thanh Nguyen, Qi Dou, Carol Y. Cheung
   Advancing Diabetic Macular Edema from 3D Optical Coherence Tomogroaphy Scans; Integrating Privacy-Preserving AI and Generalizability Techniques- A Prospective Validation in Vietnam. NEJM AI
9. Li J, Guan Z, Wang J, Cheung CY, Zheng Y, Lim LL, Lim CC, Ruamviboonsuk P, Raman R, Corsino L, Echouffo-Tcheugui JB, Luk AOY, Chen LJ, Sun X, Hamzah H, Wu Q, Wang X, Liu R, Wang YX, Chen T, Zhang X, Yang X, Yin J, Wan J, Du W, Quek TC, Goh JHL, Yang D, Hu X, Nguyen TX, Szeto SKH, Chotcomwongse P, Malek R, Normatova N, Ibragimova N, Srinivasan R, Zhong P, Huang W, Deng C, Ruan L, Zhang C, Zhang C, Zhou Y, Wu C, Dai R, Koh SWC, Abdullah A, Hee NKY, Tan HC, Liew ZH, Tien CS, Kao SL, Lim AYL, Mok SF, Sun L, Gu J, Wu L, Li T, Cheng D, Wang Z, Qin Y, Dai L, Meng Z, Shu J, Lu Y, Jiang N, Hu T, Huang S, Huang G, Yu S, Liu D, Ma W, Guo M, Guan X, Yang X, Bascaran C, Cleland CR, Bao Y, Ekinci EI, Jenkins A, Chan JCN, Bee YM, Sivaprasad S, Shaw JE, Simó R, Keane PA, Cheng CY, Tan GSW, Jia W, Tham YC, Li H, Sheng B, Wong TY. Integrated image-based deep learning and language models for primary diabetes care. Nat Med. 2024 Jul 19. doi: 10.1038/s41591-024-03139-8. Epub ahead of print. PMID: 39030266.
10. Szeto SKH#, Tsang CW, Mohamed S, Lee GKY, Lok JKH, Hui VWK, Tsang KK, Chen LJ, Brelen ME, Lai TYY. Displacement of submacular hemorrhage using subretinal cocktail injection versus pneumatic displacement: a real-world comparative study. Ophthalmologica 2024 Feb 26. doi: 10.1159/000537953. Epub ahead of print. PMID: 38408445.
11. Lam C, Wong YL, Tang Z, Hu X, Nguyen TX, Yang D, Zhang S, Ding J, Szeto SKH, Ran AR, Cheung CY. Performance of Artificial Intelligence in Detecting Diabetic Macular Edema From Fundus Photography and Optical Coherence Tomography Images: A Systematic Review and Meta-analysis. Diabetes Care. 2024 Feb 1;47(2):304-319. doi: 10.2337/dc23-0993. PMID: 38241500.
12. Simon KH.Szeto#, Timothy YY. Lai, Stela Vujosevic , Jennifer K. Sun, SriniVas R. Sadda, Gavin Tan, Sobha Sivaprasad, Tien Y. Wong, Carol Y.  Optical coherence tomography in the management of diabetic macular oedema. Prog Retin Eye Res. 2023 Nov 7. doi: 10.1016/j.preteyeres.2023.101220.
13. Zhang XJ, Chen XN, Tang FY, Szeto S, Ling XT, Lin ZX, Tham CC, Pang CP, Chen LJ, Yam JC. Pathogenesis of myopic choroidal neovascularization: A systematic review and meta-analysis. Surv Ophthalmol (IF: 5.1, citation: 2). 2023 Jul 28:S0039-6257(23)00101-7. doi: 10.1016/j.survophthal.2023.07.006. Epub ahead of print. PMID: 37517683.;
14. Yang D, Tang Z, Ran A, Nguyen TX, Szeto S, Chan J, Wong CYK, Hui V, Tsang K, Chan CKM, Tham CC, Sivaprasad S, Lai TYY, Cheung CY. Assessment of Parafoveal Diabetic Macular Ischemia on Optical Coherence Tomography Angiography Images to Predict Diabetic Retinal Disease Progression and Visual Acuity Deterioration. JAMA Ophthalmol (IF:8.253, citation: 11) . 2023 May 25:e231821. doi: 10.1001/jamaophthalmol.2023.1821. Epub ahead of print. PMID: 37227703; PMCID: PMC10214181.
15. Szeto SK#, Hui VWK, Tang FY, Yang D, Sun ZH, Mohamed S, Chan CKM, Lai TYY, Cheung C. OCT-based biomarkers for predicting treatment response in eyes with centre-involved diabetic macular oedema treated with anti-VEGF injections: a real-life retina clinic-based study. Br J Ophthalmol. 2023 Apr;107(4):525-533. doi: 10.1136/bjophthalmol-2021-319587. Epub 2021 Nov 8. PMID: 34750100.
16. Szeto SKH#, Hui VWK, Vivianna Siu, Mohamed S, Chan CKM, Hsieh YT, Tan CS, Chhablani J, Lai TYY, Ng DSC. Recent Advances in Clinical Applications of Imaging in Retinal Diseases. Asia Pac J Ophthalmol (Phila)
17. Szeto SKH#*, Mohamed S, Tsang CW, Lai TYY, Hui VWK, Chan CKM. Multimodal imaging features of choroidal metastasis of non-small-cell lung cancer: a case report. Hong Kong J Ophthalmol. 19];26(2)
18. Lai TYY, Tang Z, Lai ACW, Szeto SKH, Lai RYK, Cheung CY. Association of Fundus Autofluorescence Abnormalities and Pachydrusen in Central Serous Chorioretinopathy and Polypoidal Choroidal Vasculopathy. J Clin Med
19. Yang DW, Tang ZQ, Tang FY, Szeto SK, Chan J, Yip F, Wong CY, Ran AR, Lai TY, Cheung CY. Clinically relevant factors associated with a binary outcome of diabetic macular ischaemia: an OCTA study. Br J Ophthalmol
20. Hui VWK, Szeto SKH, Tang F, Yang D, Chen H, Lai TYY, Rong A, Zhang S, Zhao P, Ruamviboonsuk P, Lai CC, Chang A, Das T, Ohji M, Huang SS, Sivaprasad S, Wong TY, Lam DSC, Cheung CY. Optical Coherence Tomography Classification Systems for Diabetic Macular Edema and Their Associations With Visual Outcome and Treatment Responses – An Updated Review. Asia Pac J Ophthalmol (Phila) 2021 Dec 17. doi: 10.1097/APO.0000000000000468. Epub ahead of print. PMID: 34923521.
21. Szeto SK#*, Mohamed S, Tsang CW, Chan CK. Massive retinal infiltrates as the presenting sign of chronic myeloid leukemia: Clinical and imaging features of leukemic retinopathy. Eur J Ophthalmol (IF: 1.9, citation:0). 2021 Oct 1:11206721211048792. doi: 10.1177/11206721211048792. Epub ahead of print. PMID: 34595942.
22. Yang D, Sun Z, Shi J, Ran A, Tang F, Tang Z, Lok J, Szeto S, Chan J, Yip F, Zhang L, Meng Q, Rasmussen M, Grauslund J, Cheung CY. A MULTITASK DEEP-LEARNING SYSTEM FOR ASSESSMENT OF DIABETIC MACULAR ISCHEMIA ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IMAGES. Retina. 2022 Jan 1;42(1):184-194. doi: 10.1097/IAE.0000000000003287. PMID: 34432726.
23. Tang F, Wang X, Ran AR, Chan CKM, Ho M, Yip W, Young AL, Lok J, Szeto S, Chan J, Yip F, Wong R, Tang Z, Yang D, Ng DS, Chen LJ, Brelén M, Chu V, Li K, Lai THT, Tan GS, Ting DSW, Huang H, Chen H, Ma JH, Tang S, Leng T, Kakavand S, Mannil SS, Chang RT, Liew G, Gopinath B, Lai TYY, Pang CP, Scanlon PH, Wong TY, Tham CC, Chen H, Heng PA, Cheung CY. A Multitask Deep-Learning System to Classify Diabetic Macular Edema for Different Optical Coherence Tomography Devices: A Multicenter Analysis. Diabetes Care (IF: 14.8, citation:35).. 2021 Sep;44(9):2078-2088. doi: 10.2337/dc20-3064. Epub 2021 Jul 27. PMID: 34315698; PMCID: PMC8740924.
24. Tang F, Luenam P, Ran AR, Quadeer AA, Raman R, Sen P, Khan R, Giridhar A, Haridas S, Iglicki M, Zur D, Loewenstein A, Negri HP, Szeto S, Lam BKY, Tham CC, Sivaprasad S, Mckay M, Cheung CY. Detection of Diabetic Retinopathy from Ultra-Widefield Scanning Laser Ophthalmoscope Images: A Multicenter Deep Learning Analysis. Ophthalmol Retina (IF:4.4, citation:46). 2021 Nov;5(11):1097-1106. doi: 10.1016/j.oret.2021.01.013. Epub 2021 Feb 1. PMID: 33540169.
25. Tang Z, Chan MY, Leung WY, Wong HY, Ng CM, Chan VTT, Wong R, Lok J, Szeto S, Chan JCK, Tham CC, Wong TY, Cheung CY. Assessment of retinal neurodegeneration with spectral-domain optical coherence tomography: a systematic review and meta-analysis. Eye (Lond) 2021 May;35(5):1317-1325. doi: 10.1038/s41433-020-1020-z. Epub 2020 Jun 24. PMID: 32581390; PMCID: PMC8182828.
26. Tang FY, Chan EO, Sun Z, Wong R, Lok J, Szeto S, Chan JC, Lam A, Tham CC, Ng DS, Cheung CY. Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes. Eye Vis (Lond) 2020 Feb 3;7:7. doi: 10.1186/s40662-019-0173-y. PMID: 32025523; PMCID: PMC6996172.
27. Sun Z, Tang F, Wong R, Lok J, Szeto SKH, Chan JCK, Chan CKM, Tham CC, Ng DS, Cheung CY. OCT Angiography Metrics Predict Progression of Diabetic Retinopathy and Development of Diabetic Macular Edema: A Prospective Study. Ophthalmology. 2019 Dec;126(12):1675-1684. doi: 10.1016/j.ophtha.2019.06.016. Epub 2019 Jun 26. Erratum in: Ophthalmology (IF:12.4, citation:250). 2020 Dec;127(12):1777. PMID: 31358386.
28. Tang F, Sun Z, Wong R, Lok J, Lam A, Tham CC, Chan CK, Mohamed S, Lam TC, Szeto SK, Ng DS, Cheung CY. Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study. Br J Ophthalmol (IF: 3.9, citation:22). 2018 Jun 4:bjophthalmol-2017-312010. doi: 10.1136/bjophthalmol-2018-312010. Epub ahead of print. PMID: 29866787.
29. Szeto SKH#, Wong R, Lok J, Tang F, Sun Z, Tso T, Lam TCH, Tham CC, Ng DS, Cheung CY. Non-mydriatic ultrawide field scanning laser ophthalmoscopy compared with dilated fundal examination for assessment of diabetic retinopathy and diabetic macular oedema in Chinese individuals with diabetes mellitus. Br J Ophthalmol . 2019 Sep;103(9):1327-1331. doi: 10.1136/bjophthalmol-2018-311924. Epub 2018 Oct 31. PMID: 30381391.
30. Szeto SK#, Chan TC, Wong RL, Ng AL, Li EY, Jhanji V. Prevalence of Ocular Manifestations and Visual Outcomes in Patients With Herpes Zoster Ophthalmicus . Cornea. 2017 Mar;36(3):338-342. doi: 10.1097/ICO.0000000000001046. PMID: 27741018.

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