Calvin CP PANG

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  5. Calvin CP PANG

S. H. Ho Research Professor of Visual Sciences

BSc (Lond), DPhil (Oxon), FARVO

Contact :

(852) 3943 5801

cppang@cuhk.edu.hk

Academic Appointments

  • S. H. Ho Research Professor of Visual Sciences, Chinese University of Hong Kong (CUHK)
  • Director, Joint Shantou International Eye Center (JSIEC) of Shantou University and The Chinese University of Hong Kong

Biography

Prof Pang was appointed Professor in Ophthalmology and Visual Sciences, CUHK, in 2008 and bestowed the S. H. Ho Professorship in Visual Sciences in 2010. From 2012 to 2015 Prof Pang was Chairman of the Department. Since 2012 he has been Director of the Shantou University/CUHK Joint Shantou International Eye Center.

Prof Pang pioneered research on molecular genetics and genomics of eye diseases in Hong Kong. His other research interests include pharmacokinetics of green tea catechins, and GHRH receptor antagonists in ocular oxidative stress, inflammation, and degeneration. Prof Pang also works on risk factors and prevention of children eye diseases and childhood myopia, and advocates the concept of ‶health care through children eye care″.

Prof Pang has delivered more than 200 invited lectures locally, nationally, and internationally. He received the China State Scientific and Technological Progress Award (SSTPA) second-class award in 2016, Special Achievement Award of Chinese Ophthalmological Society in 2017, and Asia-Pacific Academy of Ophthalmology (APAO) Senior Achievement Award, in 2018. In 2017 Prof Pang delivered the National Institute of Health – Global Health Vision Lecture, Bethesda, USA. In 2018 Prof Pang became a Fellow of the Association of Research in Vision and Ophthalmology (ARVO, USA) and has been honoured as the 2020 ARVO Foundation honoree. In 2021, Prof Pang was conferred ′Honorary Fellow′ of the College of Ophthalmologists of Hong Kong. In 2022, he received the APAO Outstanding Service in Prevention of Blindness Award. In 2024, Prof Pang has been selected for ‶The Ophthalmologist Power List″, top 100 most influential individuals in the field of ophthalmology, including clinical doctors, professors, and scientists, by an international publication, ‶The Ophthalmologist″.

Research Areas

  1. Molecular genomics, gene mapping and identification, genome wide association study (GWAS), and whole exome sequencing (WES), on complex eye diseases: primary open angle glaucoma, primary angle closure glaucoma, age-related macular degeneration, polypoidal choroidal vasculopathy, central serous chorioretinopathy, myopia, uveitis, and thyroid eye diseases.
  2. Molecular genetics and risk factors: glaucoma, macular diseases, retinoblastoma, diabetic retinopathy, myopia, uveitis, and thyroid eye diseases.
  3. Animal models of eye diseases: optic nerve crush, elevated IOP, retina degeneration, experimental induced uveitis, and experimental autoimmune uveoretinitis.
  4. Pharmacokinetics and potential therapeutic effects of green tea extract, catechins, neuropeptides as agonists and antagonists of growth hormone-releasing hormone receptor in ocular oxidative stress, inflammations, and degeneration.
  5. Risk factors, genetics and prevention of children eye diseases and childhood myopia. The concept of health care through children eye care.
  6. Contemporary medical issues such as ophthalmic effects of Covid-19.

Academic Activities

Vice-President Asia-Pacific Myopia Society
Convener Visual Sciences Program, World Ophthalmology Congresses (WOC) 2016, 2018, 2020
Scientific Program Committee and Convener Visual Sciences program of Asia Pacific Congresses of Ophthalmology (APAO). 2018, 2019, 2020, 2022, 2023, 2024
Co-chair Asia ARVO 2015
Member ARVO Strategic Plan Steering Committee, Global Presence Pillar 2014, 2015

Research Highlights

Research Programmes

  1. Molecular genetics, gene identification, GWAS, and WES on primary open angle glaucoma, primary angle closure glaucoma, age-related macular degeneration, polypoidal choroidal vasculopathy, central serous chorioretinopathy, myopia, and thyroid eye diseases.
  2. Studies on glaucoma, complex macular diseases, retinoblastoma, myopia, and thyroid eye disease.
  3. Animal models of eye diseases for studies in green tea catechins and GHRH receptor antagonists in ocular oxidative stress and inflammation.
  4. Children eye diseases: retinoblastoma, refractive errors, ocular traits, myopia prevention, epidemiology, genetics. Concept of ′Child health through children eye care′.

Accomplishments

  1. Identification of novel gene loci and variants for complex eye diseases through international consortiums and collaborations.
  2. Identification of new genes and gene variants of complex eye diseases with Prof. Guy LJ CHEN and genetics team.
  3. Establishment of ethnic differentiations in glaucoma, AMD and PCV genes.
  4. Confirmation of the involvements of ocular inflammation of the GHRH-GH-IGF1 Axis and therapeutic potential of GHRH-R antagonists with Dr CHU Wai Kit, Dr LP Cen, Prof. SO Chan and laboratory-based teams.
  5. Establishment of the anti-oxidative properties and therapeutic potential of green tea catechins.
  6. Establishment of AI (artificial intelligence) protocols in ophthalmology with CUHK and JSIEC AI teams.
  7. Discoveries and remedies of ophthalmic issues due to COVID-19 with CUHK COVID-19 study teams.
  8. Establishment of risk factors of childhood myopia and treatment protocols for prevention of progression with Dr Jason CS YAM and Children Eye Study team.
  9. Recipient of the China State Scientific and Technological Progress Award (2016), Special Achievement Award Chinese Ophthalmological Society (2017), Honorary Fellow, HK College of Ophthalmologists (2021) and ARVO honoree (2021).

Representative Publications:

  1. >590 papers in international indexed peer reviewed journals, 28 book chapters, edition of 3 journal special issues and 1 book. Citation metrics as of April 2024 Google Scholar: Sum of the Times Cited: >26,500. h-index: 84.

 

Selected Publications

*corresponding or senior author

  1. Zhang G, Chen W, Chen H, Lin J, Cen LP, Xie P, Zheng Y, Ng TK, Brelén ME, Zhang M, Pang CP*. Risk factors for diabetic retinopathy, diabetic macular edema, and sight-threatening diabetic retinopathy. Asia Pac J Ophthalmol (Phila). 2024 May 13:100067
  2. Ng TK, Chu KO, Wang CC, Pang CP*. Green Tea Catechins as Therapeutic Antioxidants for Glaucoma Treatment. Antioxidants. 2023 Jun; 12(7):1320
  3. Chan PP, Lee VWY, Yam JC, Brelén ME, Kit CW, Wan KH, Chen LJ, Tham CC, Pang CP*. Flipped Classroom Case Learning vs Traditional Lecture-Based Learning in Medical School Ophthalmology Education: A Randomized Trial. Acad Med. 2023 Apr 14.
  4. Zhang XJ, Zhang Y, Kam KW, … Pang CP*,Yam JC. Prevalence of Myopia in Children Before, During, and After COVID-19 Restrictions in Hong Kong. JAMA Netw Open. 2023 Mar 1;6(3):e234080.
  5. Yam JC, Zhang XJ, Zhang Y, Yip BHK, Tang F, Wong ES, Bui CHT, Kam KW, Ng MPH, Ko ST, Yip WWK, Young AL, Tham CC, Chen LJ, Pang CP*. Effect of Low-Concentration Atropine Eyedrops vs Placebo on Myopia Incidence in Children: The LAMP2 Randomized Clinical Trial. JAMA. 2023 Feb 14;329(6):472-481.
  6. Cen LP, Ng TK, Chu WK, Pang CP*. Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection. Neural Regen Res. 2022 Dec;17:2643-2648.
  7. Yam JC, Zhang XJ, Zhang Y, Wang YM, Tang SM, Li FF, Kam KW, Ko ST, Yip BHK, Young AL, Tham CC, Chen LJ, Pang CP*. Three-Year Clinical Trial of Low-Concentration Atropine for Myopia Progression Study: Continued Versus Washout: Phase 3 Report. Ophthalmology. 2022 Mar;129:308-321.
  8. Wong ES, Choy RW, Zhang Y, Chu WK, Chen LJ, Pang CP*, Yam JC. Global retinoblastoma survival and globe preservation: a systematic review and meta-analysis of associations with socioeconomic and health-care factors. Lancet Glob Health. 2022 Mar;10(3):e380-e389.
  9. Cen LP, Ng TK, Liang JJ, Xu C, Zhuang X, Liu YF, Chen SL, Xu Y, Yang Q, Yuan XL, Qin YJ, Chan SO, Chen H, Zhang M, Schally AV, Pang CP*. Agonist of growth hormone-releasing hormone enhances retinal ganglion cell protection induced by macrophages after optic nerve injury. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):e1920834118.
  10. Cen LP, Ji J, Lin JW, Ju ST, Lin HJ, Li TP, Wang Y, Yang JF, Liu YF, Tan S, Tan L, Li D, Wang Y, Zheng D, Xiong Y, Wu H, Jiang J, Wu Z, Huang D, Shi T, Chen B, Yang J, Zhang X, Luo L, Huang C, Zhang G, Huang Y, Ng TK, Chen H, Chen W, Pang CP*, Zhang M. Automatic detection of 39 fundus diseases and conditions in retinal photographs using deep neural networks. Nat Commun. 2021 Aug 10;12(1):4828.
  11. Li C, Chen LJ, Chen X, Zhang M, Pang CP*, Chen H. Retrospective analysis of the possibility of predicting the COVID-19 outbreak from Internet searches and social media data, China. Euro Surveill. 2020 Mar;25(10):2000199.
  12. Yam JC, Jiang Y, Tang SM, Law AKP, Chan JJ, Wong E, Ko ST, Young AL, Tham CC, Chen LJ, Pang CP*. Low-concentration Atropine for Myopia Progression (LAMP) Study: A randomized, double-blinded, placebo-controlled trial of 0.05%, 0.025% and 0.01% Atropine eye drops in myopia control. 2019 Jan; 126(1):113-124.
  13. Chu KO, Chan KP, Chan SO, Ng TK, Jhanji V, Wang CC, Pang CP*. Metabolomics of Green-Tea Catechins on Vascular-Endothelial-Growth-Factor-Stimulated Human-Endothelial-Cell Survival. J Agric Food Chem. 2018;66(48):12866-12875.
  14. Chu WK, Law KS, Chan SO, Yam JC, Chen LJ, Zhang H, Cheung HS, Block NL, Schally AV, Pang CP*. Antagonists of growth hormone-releasing hormone receptor induce apoptosis specifically in retinoblastoma cells. Proc Natl Acad Sci U S A. 2016 Dec 13;113:14396-14401.
  15. Huang L, Zhang H, Cheng CY, Wen F, …., Zhou Y, Iijima H, Honda S, Lei C, Zhang L, Zheng H, Jiang D, Zhu X, Wong TY, Khor CC, Pang CP*, Yoshimura N, Yang Z. A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy. Nat Genet. 2016 Jun;48(6):640-7.
  16. Chen LJ, Ma L, Chu WK, Lai TY, Chen H, Brelén ME, Rong SS, Young AL, Tam PO, Zhang M, Pang CP*. Identification of PGF as a New Gene for Neovascular Age-Related Macular Degeneration in a Chinese Population. Invest Ophthalmol Vis Sci. 2016 Apr;57:1714-20.
  17. Qin YJ, Chan SO, Chong KK, Li BF, Ng TK, Yip YW, Chen H, Zhang M, Block NL, Cheung HS, Schally AV, Pang CP*. Antagonist of GH-releasing hormone receptors alleviates experimental ocular inflammation. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18303-8.
  18. Chen Y, Lin Y, Vithana EN, Jia L, Zuo X, Wong TY, Chen LJ, Zhu X, Tam PO, Gong B, Qian S, Li Z, Liu X, Mani B, Luo Q, Guzman C, Leung CK, Li X, Cao W, Yang Q, Tham CC, Cheng Y, Zhang X, Wang N, Aung T, Khor CC, Pang CP*, Sun X, Yang Z. Common variants near ABCA1 and in PMM2 are associated with primary open-angle Nat Genet. 2014 Oct;46 (10):1115-9.
  19. Liu K, Chen LJ, Lai TY, Tam PO, Ho M, Chiang SW, Liu DT, Young AL, Yang Z, Pang CP*. Genes in the high-density lipoprotein metabolic pathway in age-related macular degeneration and polypoidal choroidal vasculopathy. 2014 Apr;121:911-6.
  20. Liu K, Chen LJ, Tam PO, Shi Y, Lai TY, Liu DT, Chiang SW, Yang M, Yang Z, Pang CP*. Associations of the C2-CFB-RDBP-SKIV2L locus with age-related macular degeneration and polypoidal choroidal vasculopathy. Ophthalmology. 2013 Apr;120(4):837-43.
  21. Vithana EN, Khor CC, Qiao C, Nongpiur ME, George R, Chen LJ, …… Pang CP*, Wang N, Aung T. Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. Nat Genet. 2012 Oct;44:1142-6.
  22. Thorleifsson G, Walters GB, Hewitt AW, Masson G, Helgason A, …… Hammond CJ, Thordarson K, Zhang M, Wadelius C, Lotery AJ, Trembath RC, Pang CP, Hoh J, Craig JE, Kong A, Mackey DA, Jonasson F, Thorsteinsdottir U, Stefansson K. Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. Nat Genet. 2010 Oct;42:906-9.
  23. Fan BJ, Wang DY, Tham CC, Lam DS, Pang CP*. Gene expression profiles of human trabecular meshwork cells induced by triamcinolone and dexamethasone. Invest Ophthalmol Vis Sci. 2008;49:1886-97
  24. Wang DY, Fan BJ, Chua JK, Tam PO, Leung CK, Lam DS, Pang CP*. A genome-wide scan maps a novel juvenile-onset primary open-angle glaucoma locus to 15q. Invest Ophthalmol Vis Sci. 2006;47:5315-21.
  25. DeWan A, Liu M, Hartman S, Zhang S, Liu DTL, Zhao C, Tam POS, Chan WM, Lam DSC, Snyder M, Barnstable C, Pang CP*, Hoh J. HTRA serine protease predisposes Asians to age-related macular degeneration. Science Nov 2006;314:989-992.

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In the Media

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