Dr YAM Cheuk Sing Jason

Assistant Professor

MBBS (HKU), MPH (HKU), FRCS (Edin), FCOphth (HK), FHKAM (Ophth)

Contact :

(852) 3943 5815

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(852) 3943 5886

Academic Appointments

  • Assistant Professor, Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong
  • Director, CUHK Jockey Club Children Eye Care Programme
  • Head, Pediatric Ophthalmology and Strabismus Service, Hong Kong Eye Hospital
  • Treasurer, Hong Kong Ophthalmological Society (HKOS)
  • Training Subcommittee, College of Ophthalmologist of Hong Kong (COHK)
  • Secretary-General, Asia-Pacific Strabismus and Pediatric Ophthalmology Society (APSPOS)
  • Society Representative (APSPOS), International Council of Ophthalmology (ICO)
  • Society Relations & Leadership Development Committee, International Council of Ophthalmology (ICO)
  • Secretary of Public Education Standing Committee, Asia Pacific Academy of Ophthalmology (APAO)
  • Council Member (Hong Kong), International Pediatric Ophthalmology and Strabismus Council (IPOSC)
  • Non-Strabismus Consultant Leader, World Society of Pediatric Ophthalmology and Strabismus (WSPOS)
  • International Programme Committee, American Association for Paediatric Ophthalmology and Strabismus (AAPOS)

Biography

Dr. Jason Yam is Assistant Professor at Department of Ophthalmology and Visual Sciences of CUHK, and Head of Pediatric Ophthalmology and Strabismus service at Hong Kong Eye Hospital. Dr. Jason Yam graduated as Bachelor of Medicine and Bachelor of Surgery from the University of Hong Kong in 2005. He received overseas training on Pediatric Ophthalmology and Strabismus in Great Ormond Street Hospital (2011); with Dr. David Guyton of Johns Hopkins Hospital (2011); and with Dr. Kenneth Wright in Los Angeles (2012); ocular genetics with Dr. Janey Wiggs of Harvard Medical School (2016); with Dr. Alex Levin of Wills Eye Hospital (2017); and Baylor College of Medicine at Texas Children Hospital (2017); ocular oncology and retinoblastoma with Dr. Jerry Shields and Dr. Carol Shields of Wills Eye Hospital (2017).

He had more than 40 publications and authored 2 book chapters; and co-authored 1 book; He is the principal investigator of research grants of more than 6 million HKD. He had delivered more than 40 presentations and invited lectures in international conferences. He also serves as an editor in Scientific Reports, Asia Pacific Journal of Ophthalmology, and Hong Kong Journal of Ophthalmology; and reviewers of 10 international journals. His awards include Hong Kong Society of Community Medicine Prize (2003), Dr Timothy Kai-Ching Liu Memorial Fund Award (2009), Distinguished Young Fellow in Hong Kong Academy of Medicine (2013), APAO Tano Travel Grant (2014), World Ophthalmology Congress Travel Grant (2014), APAO Leadership Development Program Award (2015), APAO Distinguished Service Award (2016), APAO Achievement Award (2016), and Hospital Authority Corporate Scholarship (2016), Asia-Pacific Strabismus and Paediatric Ophthalmology Society (APSPOS) Young Investigator Award (2017).

Research Areas

  1. Children Eye Studies: territory-based epidemiology, etiology, prevention, intervention, and molecular genetics of children eye diseases.
  2. Myopia: epidemiology, risk factors, genomic investigations, gene mapping and interventions in prevention of progression.
  3. Retinoblastoma: etiology and novel treatment modes.
  4. Intermittent exotropia: the clinical course, new methods in evaluation of the control, effective surgical approaches, surgical advancements, and prognostic factors of the surgical outcomes
  5. Genetic eye diseases: phenotypic characterization, family linkage, genomic investigations, and gene mapping of early onset glaucoma, congenital glaucoma, congenital cataracts, inherited retinal diseases, inherited corneal diseases and dysfunctions.
  6. Retinopathy of prematurity: prevention, and treatment.
Paediatric Ophthalmology & Strabismus Subspecialty Liaison World Ophthalmology Congress 2018 (Spain)
Paediatric Ophthalmology & Strabismus Host Coordinator Asia-Pacific Academy Ophthalmology Congress 2018 (Hong Kong)
Congress President Asia-Pacific Strabismus and Paediatric Ophthalmology Society Congress 2017 (Hong Kong)
Pediatric Ophthalmology & Strabismus Programme Secretary Asia-Pacific Academy Ophthalmology 2017 Congress, (Singapore)
Pediatric Ophthalmology and Strabismus Programme Subspecialty Liaison World Ophthalmology Congress 2016 (Mexico)
Pediatric Ophthalmology & Strabismus Programme Secretary Asia-Pacific Academy Ophthalmology Congress 2016 (Taipei)

Research Programmes

  1. Children Eye Studies: territory-based epidemiology, etiology, prevention, intervention, and molecular genetics of children eye diseases.
  2. Myopia: epidemiology, risk factors, genomic investigations, gene mapping and interventions in prevention of progression.
  3. Retinoblastoma: etiology and novel treatment modes.
  4. Intermittent exotropia: the clinical course, new methods in evaluation of the control, effective surgical approaches, surgical advancements, and prognostic factors of the surgical outcomes
  5. Genetic eye diseases: phenotypic characterization, family linkage, genomic investigations, and gene mapping of early onset glaucoma, congenital glaucoma, congenital cataracts, inherited retinal diseases, inherited corneal diseases and dysfunctions.
  6. Retinopathy of prematurity: prevention, and treatment.

Results of Note

  1. Our team has received over USD 6.5 million in research funding, from University Grant Committee, Food and Health Bureau, United Bank of Switzerland Optimus Foundation, Children’s Cancer Foundation, and Hong Kong Jockey Club Charities Trust.
  2. Our team has conducted the Low-Concentration Atropine for Myopia Progression (LAMP) trial, which was the first placebo-controlled RCT of 438 subjects to provide evidence for 0.05% atropine on myopia control, and has changed the treatment paradigm of myopia progression worldwide. This confers clinical impact to millions of children.
  3. Our team is conducting the Hong Kong Children Eye Study, an epidemiological cohort of 30,000 children and their parents for detailed phenotypic and genotypic characterization.
  4. We are the only tertiary centre in Hong Kong to manage all retinoblastoma cases. We have launched the city-wide “Hong Kong Retinoblastoma Awareness and Education Campaign” to promote early detection of retinoblastoma in Hong Kong.
  5. Our work has established the role of convergence fusion as important parameter to assess the control of intermittent exotropia and to predict its progression. This has objectified the timing of surgical intervention for intermittent exotropia.
  6. The PI has been awarded the prestigious Hospital Authority Corporate Scholarship on “Paediatric Ocular Genetics”, and was commissioned to launch this service in Hong Kong.
  7. Our works has been recognized internationally. The PI has been awarded the Asia-Pacific Strabismus and Paediatric Ophthalmology Society Young Investigator Award (2017), and Asia-Pacific Academy of Ophthalmology Distinguished Service Award (2016)

Representative Publications:

  1. Yam JC#, Jiang Y, Tang SM, Law AK, Chan JJ, Wong E, Ko ST, Young AL, Tham CC, Chen LJ, Pang CP. Low-concentration Atropine for Myopia Progression Study (LAMP): One-year result of a Randomized, Double-Blinded, Placebo-Controlled Trial on Atropine 0.05%, 0.025%, and 0.01%. Ophthalmology 2018 (In Press).
  2. Cheung CY, Li J, Lam A, Tang FY, Tham CC, Pang CP, Chen LJ, Yam JC#. Quantitative Retinal Microvasculature in Children using Swept-Source Optical Coherence Tomography: The Hong Kong Children Eye Study. Br J Ophthalmol 2018 Jun 28
  3. Tang SM, Lau T, Rong SS, Yazar S, Chen LJ, Mackey DA, Pang CP, Yam JC#. Serum vitamin D and its pathway genes in myopia: a systematic review and meta-analysis. Br J Ophthalmol 2018 Jul 17
  4. Yim CL, Tam M, Chan HL, Tang SM, Au SC, Yip WW, Ko ST, Rong SS, Chen LJ, Ng DS, Yam JC#. Antenatal steroid reduces risk of retinopathy of prematurity: A systematic review and meta-analysis. Br J Ophthalmol 2018 April 9.
  5. Tang SM, Li M, Lu SY, Kam KW, Tam PO, Young AL, Pang CP, Yam JC#, Chen LJ#. Association of the PAX6 gene with extreme myopia rather than lower-grade myopias. Br J Ophthalmol 2018 Apr;102(4):570-574
  6. Wong ES, Lam CP, Lau FH, Lau WW, Yam JC#. Botulinum toxin as an initial therapy for management of sixth nerve palsies caused by nasopharyngeal carcinomas. Eye 2018 Apr;32(4):768-774
  7. Chu WK, Law KS, Chan SO, Yam JC, Chen LJ, Zhang H, Cheung HS, Block NL, Schally AV, Pang CP. Antagonists of growth hormone-releasing hormone receptor induce apoptosis specifically in retinoblastoma cells. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14396-14401.
  8. Tang SM, Chan RY, Bin Lin S, Rong SS, Lau HH, Lau WW, Yip WW, Chen LJ, Ko ST, Yam JC#. Refractive Errors and Concomitant Strabismus: A Systematic Review and Meta-analysis. Sci Rep. 2016 Oct 12;6:35177.
  9. Chan PY, Tang SM, Au CL, Rong SS, Ng DS, Chen LJ, Yam JC#. Association of gestational hypertensive Disorders with retinopathy of prematurity: A systematic review and meta-analysis. Sci Rep. 2016 Aug 5;6:30732.
  10. Chan JT, Lam CP, Kwok MK, Wong RL, Lee GK, Lau WW, Yam JC#. Risk of recurrence of retinopathy of prematurity after initial intravitreal ranibizumab therapy. Sci Rep. 2016 Jun 1;6:27082.
  11. Kwok JJ, Chong GS, Ko ST, Yam JC#. The natural course of intermittent exotropia along a 3-year period and the factors predicting the control deterioration. Sci Rep. 2016 Jun 3;6:27113.
  12. Luk A, Yam JC#, Lau HH, Yip WW, Young AL. Surgical Outcome of Medial Rectus Resection for Recurrent Exotropia using a novel surgical formula. J Ophthalmol. 2015;2015:758463.
  13. Lam CP, Yam JC#, Lau FH, Wong CY, Yu CB, Fan DS, Lau WW. SR and LR union suture for the treatment of myopic strabismus fixus: is scleral fixation suture necessary? BioMed Research International. 2015; 2015:470473.
  14. Au SC, Tang SM, Rong SS, Chen LJ, Yam JC#. Association between hyperglycemia and retinopathy of prematurity: a systemic review and meta-analysis. Sci Rep. 2015 Mar 13;5:9091
  15. Yam JC#, Chong GS, Wu PK, Wong US, Chan CW, Ko ST. Fusional convergence in assessing the control of intermittent exotropia: a prospective study. J AAPOS. 2013 Aug;17(4):347-51

(* co-first author; # corresponding author)

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