Dr Jason CS YAM

Associate Professor

MB BS (HK), MPH (HK), FRCSEd, FCOphth HK, FHKAM (Ophthalmology)

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(852) 3943 5815

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Academic Appointments

  • Associate Professor, Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong
  • Head, Undergraduate Division, Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong
  • Head and Honorary Associate Consultant, Paediatric Ophthalmology and Strabismus Service, Hong Kong Eye Hospital
  • Head, Ophthalmology Service, Hong Kong Children’s Hospital
  • Honorary Associate Consultant, New Territories East Cluster Ophthalmology Service
  • Director, CUHK Jockey Club Children Eye Care Programme
  • Secretary, Hong Kong Ophthalmological Society (HKOS)
  • Council Member, College of Ophthalmologist of Hong Kong (COHK)
  • Secretary-General, Asia-Pacific Strabismus and Pediatric Ophthalmology Society (APSPOS)
  • Council Member, Asia-Pacific Myopia Society (APMS)
  • Society Representative (APSPOS), International Council of Ophthalmology (ICO)
  • Society Relations & Leadership Development Committee, International Council of Ophthalmology (ICO)
  • Secretary of Public Education Standing Committee, Asia Pacific Academy of Ophthalmology (APAO)
  • Council Member (Hong Kong) & Training and Education Committee Chair, International Pediatric Ophthalmology and Strabismus Council (IPOSC)
  • International Programme Committee, American Association for Paediatric Ophthalmology and Strabismus (AAPOS)
  • Council Member, Ophthalmology Group, Chinese Pediatric Society

Biography

Dr. Jason CS YAM is Associate Professor & Undergraduate Division Head at Department of Ophthalmology and Visual Sciences of CUHK, Head of Pediatric Ophthalmology and Strabismus service at Hong Kong Eye Hospital, and Head of Ophthalmology Service at Hong Kong Children’s Hospital. He is also Director of CUHK Jockey Club Children’s Eye Care Programme. Dr. Jason CS YAM graduated as Bachelor of Medicine and Bachelor of Surgery from the University of Hong Kong in 2005. He received overseas training on Pediatric Ophthalmology and Strabismus in Great Ormond Street Hospital (2011); with Dr. David GUYTON of Johns Hopkins Hospital (2011); and with Dr. Kenneth WRIGHT in Los Angeles (2012); ocular genetics with Dr. Janey WIGGS of Harvard Medical School (2016); with Dr. Alex LEVIN of Wills Eye Hospital (2017); and Baylor College of Medicine at Texas Children Hospital (2017); ocular oncology and retinoblastoma with Dr. Jerry SHIELDS and Dr. Carol SHIELDS of Wills Eye Hospital (2017).

He serves as the Secretary-General of Asia-Pacific Strabismus and Paediatric Ophthalmology Society (APSPOS), Training and Education Committee Chair of International Paediatric Ophthalmology and Strabismus Council (IPOSC), Council Member of Asia-Pacific Myopia Society (APMS), Society Relations & Leadership Development Committee of International Council of Ophthalmology (ICO), Public Education Standing Committee Secretary, and Ophthalmic Education Standing Committee of Asia Pacific Academy of Ophthalmology (APAO), International Programme Committee of American Association for Paediatric Ophthalmology and Strabismus (AAPOS), and many other international academic positions. Nationally, he serves as the Council Member of Ophthalmology Group of Chinese Paediatric Society. Locally, he serves as Secretary of Hong Kong Ophthalmological Society (HKOS), and Council Member of College of Ophthalmologists of Hong Kong (COHK). He served as the Congress President of the Inaugural Asia-Pacific Strabismus and Paediatric Ophthalmology Society Congress 2017.

He had more than 60 publications and authored 3 book chapters; and co-authored 1 book; He is the principal investigator of research grants and external funding of 7 million USD. He is PI of Low-concentration Atropine for Myopia Progression (LAMP) study, the first placebo-controlled RCT of 438 subjects to provide evidence for 0.05% atropine on myopia control, which confers clinical impact to millions of children worldwide. He is also PI of Hong Kong Children Eye Study, an epidemiological cohort of 30,000 children and their parents for detailed phenotypic and genotypic characterization. He has chaired 20 symposia, and has delivered 1 award lecture, 6 keynote lectures, 60 invited lectures, 50 conference papers. He also serves as an editor in 7 international journals including Scientific Reports, Medicine, BMC Ophthalmology, and Asia Pacific Journal of Ophthalmology etc. In 2019, he received the prestigious Asia Pacific Academy of Ophthalmology Nakajima Award for being the most outstanding young ophthalmologist under aged 40 in Asia-Pacific. At the same year, he was also named One of the Ten Outstanding Young Persons in Hong Kong to recognize his global contributions on children eye care. His other awards include Hong Kong Society of Community Medicine Prize (2003), Dr Timothy Kai-Ching Liu Memorial Fund Award (2009), Distinguished Young Fellow in Hong Kong Academy of Medicine (2013), Asia Pacific Academy of Ophthalmology Tano Travel Grant (2014), World Ophthalmology Congress Travel Grant (2014), Asia Pacific Academy of Ophthalmology Leadership Development Program Award (2015), Asia Pacific Academy of Ophthalmology Distinguished Service Award (2016), Asia Pacific Academy of Ophthalmology Achievement Award (2016), and Hospital Authority Corporate Scholarship (2016), inaugural Asia-Pacific Strabismus and Paediatric Ophthalmology Society Young Investigator Award (2017), Asia Pacific Academy of Ophthalmology Outstanding Service in Prevention of Blindness (2019), Gold Medal for Best Original Research by Young Fellows in Hong Kong Academy of Medicine (2019), and Hospital Authority Kowloon Central Cluster Outstanding Team Award (as team leader) (2020).

Research Areas

  1. Children Eye Studies: territory-based epidemiology, etiology, prevention, intervention, and molecular genetics of children eye diseases.
  2. Myopia: epidemiology, risk factors, genomic investigations, gene mapping and interventions in prevention of progression.
  3. Retinoblastoma: etiology and novel treatment modes.
  4. Intermittent exotropia: the clinical course, new methods in evaluation of the control, effective surgical approaches, surgical advancements, and prognostic factors of the surgical outcomes
  5. Genetic eye diseases: phenotypic characterization, family linkage, genomic investigations, and gene mapping of early onset glaucoma, congenital glaucoma, congenital cataracts, inherited retinal diseases, inherited corneal diseases and dysfunctions.
  6. Retinopathy of prematurity: prevention, and treatment.
Paediatric Ophthalmology & Strabismus Subspecialty Liaison World Ophthalmology Congress 2018 (Spain)
Paediatric Ophthalmology & Strabismus Host Coordinator Asia-Pacific Academy Ophthalmology Congress 2018 (Hong Kong)
Congress President Asia-Pacific Strabismus and Paediatric Ophthalmology Society Congress 2017 (Hong Kong)
Pediatric Ophthalmology & Strabismus Programme Secretary Asia-Pacific Academy Ophthalmology 2017 Congress, (Singapore)
Pediatric Ophthalmology and Strabismus Programme Subspecialty Liaison World Ophthalmology Congress 2016 (Mexico)
Pediatric Ophthalmology & Strabismus Programme Secretary Asia-Pacific Academy Ophthalmology Congress 2016 (Taipei)

Research Programmes

  1. Children Eye Studies: territory-based epidemiology, etiology, prevention, intervention, and molecular genetics of children eye diseases.
  2. Myopia: epidemiology, risk factors, genomic investigations, gene mapping and interventions in prevention of progression.
  3. Retinoblastoma: etiology and novel treatment modes.
  4. Intermittent exotropia: the clinical course, new methods in evaluation of the control, effective surgical approaches, surgical advancements, and prognostic factors of the surgical outcomes
  5. Genetic eye diseases: phenotypic characterization, family linkage, genomic investigations, and gene mapping of early onset glaucoma, congenital glaucoma, congenital cataracts, inherited retinal diseases, inherited corneal diseases and dysfunctions.
  6. Retinopathy of prematurity: prevention, and treatment.

Results of Note

  1. Our team has received over USD 6.5 million in research funding, from University Grant Committee, Food and Health Bureau, United Bank of Switzerland Optimus Foundation, Children’s Cancer Foundation, and Hong Kong Jockey Club Charities Trust.
  2. Our team has conducted the Low-Concentration Atropine for Myopia Progression (LAMP) trial, which was the first placebo-controlled RCT of 438 subjects to provide evidence for 0.05% atropine on myopia control, and has changed the treatment paradigm of myopia progression worldwide. This confers clinical impact to millions of children.
  3. Our team is conducting the Hong Kong Children Eye Study, an epidemiological cohort of 30,000 children and their parents for detailed phenotypic and genotypic characterization.
  4. We are the only tertiary centre in Hong Kong to manage all retinoblastoma cases. We have launched the city-wide “Hong Kong Retinoblastoma Awareness and Education Campaign” to promote early detection of retinoblastoma in Hong Kong.
  5. Our work has established the role of convergence fusion as important parameter to assess the control of intermittent exotropia and to predict its progression. This has objectified the timing of surgical intervention for intermittent exotropia.
  6. The PI has been awarded the prestigious Hospital Authority Corporate Scholarship on “Paediatric Ocular Genetics”, and was commissioned to launch this service in Hong Kong.
  7. Our works has been recognized internationally. The PI has been awarded the Asia-Pacific Strabismus and Paediatric Ophthalmology Society Young Investigator Award (2017), and Asia-Pacific Academy of Ophthalmology Distinguished Service Award (2016)

Representative Publications:

  1. Yam JC#, Jiang Y, Tang SM, Law AK, Chan JJ, Wong E, Ko ST, Young AL, Tham CC, Chen LJ, Pang CP. Low-concentration Atropine for Myopia Progression Study (LAMP): One-year result of a Randomized, Double-Blinded, Placebo-Controlled Trial on Atropine 0.05%, 0.025%, and 0.01%. Ophthalmology2019 Jan;126(1):113-124. doi: 10.1016/j.ophtha.2018.05.029. Epub 2018 Jul 6.
  2. Yam JC#, Li FF, Zhang X, Tang SM, Yip BH, Kam KW, Ko ST, Young AL, Tham CC, Chen LJ, Pang CP. Two-Year Clinical Trial of the Low-concentration Atropine for Myopia Progression (LAMP) Study: Phase 2 Report. Ophthalmology 2019 De c 21. pii: S0161-6420(19)32356-5. doi: 10.1016/j.ophtha.2019.12.011.
  3. Li FF, Kam KW, Zhang YZ, Tang SM, Young AL, Chen LJ, Tham CC, Pang CP, Yam JC#. Differential Effects on Ocular Biometrics by 0.05%, 0.025%, and 0.01% Atropine in one year: Low-concentration Atropine for Myopia Progression (LAMP) Study. Ophthalmology 2020 June
  4. Yuan N, Li J, Tang S, Li FF, Lee CO, Ng MPH, Cheung CY, Tham CC, Pang CP, Chen LJ, Yam JC#. Association of Secondhand Smoking Exposure With Choroidal Thinning in Children Aged 6 to 8 Years: The Hong Kong Children Eye Study. JAMA Ophthalmol. 2019 Oct 17:1-9. doi: 10.1001/jamaophthalmol.2019.4178.
  5. Wong ES, Zhang XJ, Yuan N, Li J, Pang CP, Chen LJ, Tham CC, Cheung CY, Yam JC#. New OCT angiography metrics detects impaired macular microvasculature and correlates with decreased vision in amblyopic eyes: The Hong Kong Children Eye Study. JAMA Ophthalmol. 2020 June
  6. Tang SM, Kam KW, Chen LJ, French AN, Young AL, Rose KA, Tham CC, Pang CP, Yam JC#. Independent Influence of Parental Myopia on Childhood Myopia in a Dose-related Manner in 2055 Trios: The Hong Kong Children Eye Study. Am J Ophthalmol. 2020 May.
  7. Li J, Yuan N, Chu WK, Cheung CY, Tang SM, Li FF, Chen LJ, Kam KW, Young AL, Ip P, Tham CC, Pang CP, Yam JC#. Exposure to Secondhand Smoke in School-age Children is Associated with a Thinner Retinal Nerve Fiber Layer: The Hong Kong Children Eye Study. Am J Ophthalmol. 2020 Oct 28:S0002-9394(20)30584-5.
  8. Ho A, Cheung CY, Wong J, Tang FY, Kam KW, Young AL, Chen LJ, Wong TY, Pang CP, Tham CC, Yam JC#. Independent and Synergistic Effect of Blood Pressure and Body Mass Index on Retinal Microvasculature in Children 6-8 years: The Hong Kong Children Eye Study (Journal of American Heart Association. (In Press)
  9. Yam JC#, Tang SM, Kam KW, Chen LJ, Yu M, Law AK, Yip BH, Wang YM, Cheung CY, Ng DS, Young AL, Tham CC, Pang CP. High Prevalence of Myopia in Children and Their Parents in Hong Kong Chinese Population: the Hong Kong Children Eye Study. Acta Ophthalmologica 2020 Jan 24. doi: 10.1111/aos.14350.
  10. Cheung CY, Li J, Lam A, Tang FY, Tham CC, Pang CP, Chen LJ, Yam JC#. Quantitative Retinal Microvasculature in Children using Swept-Source Optical Coherence Tomography: The Hong Kong Children Eye Study. Br J Ophthalmol2018 Jun 28
  11. Li FF, Lu SY, Tang SM, Kam KW, Tam PO, Yip WW, Young AL, Tham CC, Pang CP, Yam JC#, Chen LJ#. Association of multiple gene variants with myopia severities and endophenotypes in children. Br J Ophthalmol 2020 Aug 14
  12. Lu SY, Tang SM, Li FF, Kam KW, Tam PO, Yip WW, Young AL, Tham CC, Pang CP, Yam JC#, Chen LJ#. Association of WNT7B and RSPO1 with Axial Length in School Children. Invest Ophthalmol Vis Sci. 2020 Aug 3
  13. Tang SM, Li M, Lu SY, Kam KW, Tam PO, Young AL, Pang CP, Yam JC#, Chen LJ#. Association of the PAX6 gene with extreme myopia rather than lower-grade myopias. Br J Ophthalmol 2018 Apr;102(4):570-574. doi: 10.1136/bjophthalmol-2017-311327. Epub 2018 Feb 7.
  14. Cheung CY, Xu D, Cheng CY, Sabanayagam C, Tham CY, Yu M, Rim TH, Chai CY, Gopinath B, Mitchell P, Poulton R, Moffitt TE, Caspi A, Yam JC, Tham CC, Jonas JB, Wang YX, Song SJ, Burrell LM, Farouque O, Li LJ, Tan G, Ting DSW, Hsu W, Lee ML, Wong TY. A deep-learning system for the assessment of cardiovascular disease risk via the measurement of retinal-vessel caliber. Nature Biomedical Engineering. 2020 Oct 12.
  15. Fabian ID, Abdallah E, Abdullahi SU…., Yam JC, Yang H, Yanga JM…Bowman R. Global Retinoblastoma Study Group. Global Retinoblastoma Presentation: Analysis by National Income Level. JAMA Oncology 2020 May 1;6(5):685-695. doi: 10.1001/jamaoncol.2019.6716.

(* co-first author; # corresponding author)

 

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