Recent Representative Publications

  1. Fang D, Tang FY, Huang H, Cheung CY, Chen H. Repeatability, interocular correlation and agreement of quantitative swept-source optical coherence tomography angiography macular metrics in healthy subjects. Br J Ophthalmol. 2019 Mar;103(3):415-420. (Impact Factor: 3.384) []
  2. Cheung CY, Chan VTT, Mok VC, Chen C, Wong TY. Potential retinal biomarkers for dementia: what is new? Curr Opin Neurol. 2019 Feb;32(1):82-91. (Impact Factor: 4.010) []
  3. Cao X, Yung J, Mak H, Leung CKS. Factors governing the transduction efficiency of adeno-associated virus in the retinal ganglion cells following intravitreal injection. Gene Ther. 2019 Jan 28. [Epub ahead of print] (Impact Factor: 3.203) []
  4. Tan NYQ, Tham YC, Koh V, Cheung CY, Aung T, Wong TY, Cheng CY. The Effect of Gender on Visual Field Sensitivity: The Singapore Chinese Eye Study. Ophthalmic Epidemiol. 2019 Jan 23:1-6. (Impact Factor: 1.297) []
  5. Dai W, Tham YC, Chee ML, Majithia S, Tan NYQ, Wong KH, Neelam K, Cheung N, Sabanayagam C, Cheung CY, Wong TY, Cheng CY. Normative pattern and determinants of outer retinal thickness in an Asian population: the Singapore Epidemiology of Eye Diseases Study. Br J Ophthalmol. 2019 Jan 18. pii: bjophthalmol-2018-313159. (Impact Factor: 3.384) []
  6. Jung NY, Han JC, Ong YT, Cheung CY, Chen CP, Wong TY, Kim HJ, Kim YJ, Lee J, Lee JS, Jang YK, Kee C, Lee KH, Kim EJ, Seo SW, Na DL. Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer’s disease. J Neurol Sci. 2019 Jan 15;396:94-101. (Impact Factor: 2.448) []
  7. Viljanen A, Soinio M, Cheung CY, Hannukainen JC, Karlsson HK, Wong TY, Hughes AD, Salminen P, Nuutila P, Vesti E, Tapp RJ. Effects of bariatric surgery on retinal microvascular architecture in obese patients. Int J Obes (Lond). 2018 Dec 5. [Epub ahead of print] (Impact Factor: 5.159) []
  8. Klein R, Lee KE, Danforth L, Tsai MY, Gangnon RE, Meuer SE, Wong TY, Cheung CY, Klein BEK. The Relationship of Retinal Vessel Geometric Characteristics to the Incidence and Progression of Diabetic Retinopathy. Ophthalmology. 2018 Nov;125(11):1784-1792. (Impact Factor: 7.479) []
  9. Szeto SKH, Wong R, Lok J, Tang F, Sun Z, Tso T, Lam TCH, Tham CC, Ng DS, Cheung CY. Non-mydriatic ultrawide field scanning laser ophthalmoscopy compared with dilated fundal examination for assessment of diabetic retinopathy and diabetic macular oedema in Chinese individuals with diabetes mellitus. Br J Ophthalmol. 2018 Oct 31. pii: bjophthalmol-2018-311924. (Impact Factor: 3.384) []
  10. Buckley BJ, Aboelela A, Minaei E, Jiang LX, Xu Z, Ali U, Fildes K, Cheung CY, Cook SM, Johnson DC, Bachovchin DA, Cook GM, Apte M, Huang M, Ranson M, Kelso MJ. 6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer. J Med Chem. 2018 Sep 27;61(18):8299-8320. (Impact Factor: 6.253) []
  11. Kumari N, Cher J, Chua E, Hamzah H, Wong TY, Cheung CY. Association of serum lutein and zeaxanthin with quantitative measures of retinal vascular parameters. PLoS One. 2018 Sep 27;13(9):e0203868. (Impact Factor: 2.766) []
  12. Lin GM, Chen MJ, Yeh CH, Lin YY, Kuo HY, Lin MH, Chen MC, Lin SD, Gao Y, Ran A, Cheung CY. Transforming Retinal Photographs to Entropy Images in Deep Learning to Improve Automated Detection for Diabetic Retinopathy. J Ophthalmol. 2018 Sep 10;2018:2159702. (Impact Factor: 1.680) []
  13. Cheung CMG, Shi Y, Tham YC, Sabanayagam C, Neelam K, Wang JJ, Mitchell P, Cheng CY, Wong TY, Cheung CYL. Correlation of Color Fundus Photograph Grading with Risks of Early Age-related Macular Degeneration by using Automated OCT-derived Drusen Measurements. Sci Rep. 2018 Aug 28;8(1):12937. (Impact Factor: 4.122) []
  14. Chan VTT, Sun Z, Tang S, Chen LJ, Wong A, Tham CC, Wong TY, Chen C, Ikram MK, Whitson HE, Lad EM, Mok VCT, Cheung CY. Spectral-Domain OCT Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis. 2018 Aug 13. pii: S0161-6420(18)30258-6. (Impact Factor: 7.479) []
  15. Wong KH, Tham YC, Nguyen DQ, Dai W, Tan NYQ, Mathijia S, Neelam K, Cheung CY, Sabanayagam C, Schmetterer L, Wong TY, Cheng CY. Racial differences and determinants of macular thickness profiles in multiethnic Asian population: the Singapore Epidemiology of Eye Diseases Study. Br J Ophthalmol. 2018 Aug 10. pii: bjophthalmol-2018-312447. (Impact Factor: 3.384) []
  16. Chen KYH, Li LJ, Wong TY, Cheung CY, Curtis N, Cheung M, Burgner DP. Macro- and Microvascular Parameters After Toxic Shock Syndrome. (Impact Factor: 2.305) []
  17. Cheung CY, Li SL, Chan N, Wong MO, Chan PP, Lai I, Baig N, Tan S, Man X, Tang F, Wang YM, Tham CC. Factors Associated With Long-term Intraocular Pressure Fluctuation in Primary Angle Closure Disease: The CUHK PACG Longitudinal (CUPAL) Study. J Glaucoma. 2018 Aug;27(8):703-710. (Impact Factor: 1.742) []
  18. Cheung CY, Li J, Yuan N, Lau GYL, Chan AYF, Lam A, Tang FY, Tham CC, Pang CP, Chen LJ, Yam JC. Quantitative retinal microvasculature in children using swept-source optical coherence tomography: the Hong Kong Children Eye Study. Br J Ophthalmol. 2018 Jun 28. pii: bjophthalmol-2018-312413. (Impact Factor: 3.384) []
  19. Koh V, Tham YC, Cheung CY, Mani B, Wong TY, Aung T, Cheng CY. Diagnostic accuracy of macular ganglion cell-inner plexiform layer thickness for glaucoma detection in a population-based study: Comparison with optic nerve head imaging parameters. PLoS One. 2018 Jun 26;13(6):e0199134. (Impact Factor:2.766) []
  20. Tang F, Sun Z, Wong R, Lok J, Lam A, Tham CC, Chan CK, Mohamed S, Lam TC, Szeto SK, Ng DS, Cheung CY. Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study. Br J Ophthalmol. 2018 Jun 4. pii: bjophthalmol-2017-312010. (Impact Factor: 3.384) []
  21. Cheung CY, Wong TY. Editorial to ‘Triple Vessel Coronary Artery Disease and Retinal Nerve Fibre Layer Thickness’. Ann Acad Med Singapore. 2018 Jun;47(6):206-207. (Impact Factor:0.819 ) []
  22. Cheung CY, Tang F, Ng DS, Wong R, Lok J, Sun Z, Tso T, Lam A, Brelén M, Chong KK, Luk AO, Chan JC, Wong TY, Tham CC. The Relationship of Quantitative Retinal Capillary Network to Kidney Function in Type 2 Diabetes. Am J Kidney Dis. 2018 Jun;71(6):916-918. (Impact Factor: 7.543) []
  23. Tan NYQ, Tham YC, Koh V, Nguyen DQ, Cheung CY, Aung T, Wong TY, Cheng CY. The Effect of Testing Reliability on Visual Field Sensitivity in Normal Eyes: The Singapore Chinese Eye Study. Ophthalmology. 2018 Jan;125(1):15-21. (Impact Factor:7.479) []
  24. Chan VTT, Tso THK, Tang F, Tham C, Mok V, Chen C, Wong TY, Cheung CY. Using Retinal Imaging to Study Dementia. J Vis Exp. 2017 Nov 6;(129). (Impact Factor: 1.184) []
  25. Ting DSW, Cheung CY, Lim G, Tan GSW, Quang ND, Gan A, Hamzah H, Garcia-Franco R, San Yeo IY, Lee SY, Wong EYM, Sabanayagam C, Baskaran M, Ibrahim F, Tan NC, Finkelstein EA, Lamoureux EL, Wong IY, Bressler NM, Sivaprasad S, Varma R, Jonas JB, He MG, Cheng CY, Cheung GCM, Aung T, Hsu W, Lee ML, Wong TY. Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes. JAMA. 2017 Dec 12;318(22):2211-2223. (Impact Factor: 47.661) []
  26. Sabanayagam C, Yip W, Gupta P, Mohd Abdul RB, Lamoureux E, Kumari N, Cheung GC, Cheung CY, Wang JJ, Cheng CY, Wong TY. Singapore Indian Eye Study 2: methodology and impact of migration on systemic and eye outcomes. Clin Exp Ophthalmol. 2017 Nov;45(8):779-789. (Impact Factor: 2.546) []
  27. Wang LZ, Cheung CY, Tapp RJ, Hamzah H, Tan G, Ting D, Lamoureux E, Wong TY. Availability and variability in guidelines on diabetic retinopathy screening in Asian countries. Br J Ophthalmol. 2017 Oct;101(10):1352-1360. (Impact Factor: 3.384) []
  28. Lu X, Chen W, Xia H, Zheng K, Jin C, Ng DSC, Chen H. Atrophy of retinal inner layers is associated with poor vision after endophthalmitis: a spectral domain optical coherence tomography study
    Eye (Lond). 2017 Oct;31(10):1488-1495. (Impact Factor: 275) []
  29. Wan KH, Leung CKS. Optical coherence tomography angiography in glaucoma: a mini-review
    2017 Sep 14;6:1686. []
  30. Chan TC, Biswas S, Yu M, Jhanji V. Comparison of corneal measurements in keratoconus using swept-source optical coherence tomography and combined Placido-Scheimpflug imaging.
    Acta Ophthalmol. 2017 Sep;95(6):e486-e494. (Impact Factor: 032) []
  31. Yip W, Ong PG, Teo BW, Cheung CY, Tai ES, Cheng CY, Lamoureux E, Wong TY, Sabanayagam C.
    Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study. Sci Rep. 2017 Aug 24;7(1):9374. (Impact Factor: 259) []
  32. Loh EH, Ong YT, Venketasubramanian N, Hilal S, Thet N, Wong TY, Chen CPL, Cheung CY. Repeatability and Reproducibility of Retinal Neuronal and Axonal Measures on Spectral-Domain Optical Coherence Tomography in Patients with Cognitive Impairment. Front Neurol. 2017 Aug 15;8:359. (Impact Factor: 552) []
  33. Benschop L, Schalekamp-Timmermans S, Roeters van Lennep JE, Jaddoe VWV, Wong TY, Cheung CY, Steegers EAP, Ikram KM. Gestational hypertensive disorders and retinal microvasculature: the Generation R Study. BMC Med. 2017 Aug 14;15(1):153. (Impact Factor: 7.901) []
  34. Zhang X, Li EY, Leung CK, Musch DC, Tang X, Zheng C, He M, Chang DF, Lam DS. Prevalence of visual impairment and outcomes of cataract surgery in Chaonan, South China. PLoS One. 2017 Aug 10;12(8):e0180769. (Impact Factor: 806) []
  35. Sharma S, Ang M, Najjar RP, Sng C, Cheung CY, Rukmini AV, Schmetterer L, Milea D. Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol. 2017 Aug;101(8):1045-1051.(Impact Factor: 3.036) []
  36. Zheng KK, Cai J, Rong SS, Peng K, Xia H, Jin C, Lu X, Liu X, Chen H, Jhanji V. Longitudinal Evaluation of Wound Healing after Penetrating Corneal Injury: Anterior Segment Optical Coherence Tomography Study. Curr Eye Res. 2017 Jul;42(7):982-986. (Impact Factor: 238) []
  37. Cheung CY, Sabanayagam C, Law AK, Kumari N, Ting DS, Tan G, Mitchell P, Cheng CY, Wong TY. Retinal vascular geometry and 6 year incidence and progression of diabetic retinopathy. Diabetologia. 2017 Jun 16. [Epub ahead of print] (Impact Factor: 6.08) []
  38. Tang FY, Ng DS, Lam A, Luk F, Wong R, Chan C, Mohamed S, Fong A, Lok J, Tso T, Lai F, Brelen M, Wong TY, Tham CCC, Cheung CY. Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes. Sci Rep. 2017 May 31;7(1):2575. (Impact Factor: 259) []
  39. Gupta P, Cheung CY. Refining the definition of the choroidal-scleral interface. Acta Ophthalmol. 2017 May;95(3):e243-e244. (Impact factor: 2.844) []
  40. Bakthavatsalam M, Ng DS, Lai FH, Tang FY, Brelén ME, Tsang CW, Lai TY, Cheung CY. Choroidal structures in polypoidal choroidal vasculopathy, neovascular age-related maculopathy, and healthy eyes determined by binarization of swept source optical coherence tomographic images.
    Graefes Arch Clin Exp Ophthalmol. 2017 May;255(5):935-943. (Impact Factor: 991) []
  41. Lee R, Tham YC, Cheung CY, Sidhartha E, Siantar RG, Lim SH, Wong TY, Cheng CY. Factors affecting signal strength in spectral-domain optical coherence tomography. Acta Ophthalmol. 2018 Feb;96(1):e54-e58. (Impact Factor: 032) []
  42. Leung CK. Evaluation of Retinal Nerve Fiber Layer Thinning With Fourier-Domain Optical Coherence Tomography. JAMA Ophthalmol. 2017 Apr 1;135(4):337-338. (Impact Factor: 4.340) []
  43. Lin C, Mak H, Yu M, Leung CK. Trend-Based Progression Analysis for Examination of the Topography of Rates of Retinal Nerve Fiber Layer Thinning in Glaucoma.
    JAMA Ophthalmol. 2017 Mar 1;135(3):189-195. (Impact Factor: 340) []
  44. Tang F, Cheung CY. Quantitative Retinal Optical Coherence Tomography Angiography in Patients With Diabetes Without Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1766. (Impact Factor: 3.427) []
  45. Wu Z, Lin C, Crowther M, Mak H, Yu M, Leung CK. Impact of Rates of Change of Lamina Cribrosa and Optic Nerve Head Surface Depths on Visual Field Progression in Glaucoma. Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1825-1833. (Impact Factor: 427) []
  46. Cheung CY, Ikram MK, Chen C, Wong TY. Imaging retina to study dementia and stroke. Prog Retin Eye Res. 2017 Mar;57:89-107. (Impact Factor: 9.394) []
  47. Ma L, Brelen ME, Tsujikawa M, Chen H, Chu WK, Lai TY, Ng DS, Sayanagi K, Hara C, Hashida N, Chan VC, Tam PO, Young AL, Chen W, Nishida K, Pang CP, Chen LJ. Identification of ANGPT2 as a New Gene for Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in the Chinese and Japanese Populations. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1076-1083. (Impact Factor: 427) []
  48. Ng DS, Bakthavatsalam M, Lai FH, Cheung CY, Cheung GC, Tang FY, Tsang CW, Lai TY, Wong TY, Brelén ME. Classification of Exudative Age-Related Macular Degeneration With Pachyvessels on En Face Swept-Source Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1054-1062. (Impact Factor: 3.427) []
  49. Sidibé D, Sankar S, Lemaître G, Rastgoo M, Massich J, Cheung CY, Tan GS, Milea D, Lamoureux E, Wong TY, Mériaudeau F. An anomaly detection approach for the identification of DME patients using spectral domain optical coherence tomography images. Comput Methods Programs Biomed. 2017 Feb;139:109-117. (Impact Factor: 862) []
  50. Chen KY, Burgner DP, Wong TY, Saw SM, Quek SC, Pang AY, Leo SW, Wong IB, Zannino D, Curtis N, Cheung M, Cheung CY, Lim TC. Evidence of Microvascular Changes in the Retina following Kawasaki Disease. Sci Rep. 2017 Jan 17;7:40513. (Impact Factor: 5.228) []