Prof Guy LJ CHEN
BMed, MMed, PhD(CUHK), FCOphthHK, FHKAM(Ophthalmology)
- Professor, Department of Ophthalmology and Visual Sciences, CUHK
- Head, Graduate Division of Ophthalmology and Visual Sciences, CUHK
- Associate Director (Medical), CUHK Jockey Club Myopia Prevention Programme
- Honorary Consultant, Department of Ophthalmology, Prince of Wales Hospital and Alice Ho Nethersole Hospital
- Honorary Consultant, Hong Kong Eye Hospital
- Honorary Associate Professor, Shantou University Medical College
Prof Chen is Professor of the Department of Ophthalmology and Visual Sciences, and Head of Graduate Division of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong. He is Honorary Consultant of the New Territories East Cluster (Prince of Wales Hospital and Alice Ho Nethersole Hospital) and Hong Kong Eye Hospital. Prof Chen is Specialist in Ophthalmology, with special interest in vitreoretinal and macular diseases.
Prof Chen is actively working on ophthalmic research. His major research interest is molecular and clinical genetics of major eye diseases, including macular and retinal diseases (e.g., age-related macular degeneration, polypoidal choroidal vasculopathy, central serous chorioretinopathy, diabetic retinopathy, retinitis pigmentosa, and other inherited retinal dystrophies), glaucoma, and myopia. He is also working on the genetic profiling of myopia progression and ocular traits development in children. Prof Chen and co-workers have identified a large number of new disease genes/loci, mutations, association profiles, and biomarkers for major eye diseases.
Prof Chen has published over 168 papers in SCI international indexed peer-reviewed journals, with an H-index of 47 (Feb 2023). He is the first or corresponding author of 56 publications. He has co-authored 1 article in JAMA (Impact factor (IF) 157.335), 7 articles in Nature Genetics (Impact factor (IF) 41.307), 1 in Lancet Oncology (IF 54.433), 1 in Lancet Global Health (IF 38.927), 4 in Nature Communication (IF 17.694), 1 in JAMA Network Open (IF 13.353), 1 in Diabetes Care (IF 17.152), 1 in PNAS (IF 12.779), 2 in American Journal of Human Genetics (IF 11.043), 12 in Ophthalmology (IF 14.277), 3 in JAMA Ophthalmology (IF 8.253), 19 in Brit J Ophthalmol (IF 5.908), 5 in American Journal of Ophthalmology (IF 5.488), and 17 in IOVS (IF 4.925).
Prof Chen is active in research grant application. He is the principal investigators of 7 major local (Hong Kong), National (China), and International competitive research grants, with a total amount of more than HK$6.3 million.
Prof Chen is also active in international service. He has delivered more than 45 lectures as invited speaker and chaired more than 10 sections in international conferences, mainly including the World Ophthalmology Congress, Asia-Pacific Academy of Ophthalmology (APAO) Congress, and International Symposium of Ophthalmology.
Major Research Awards
2020/12 Gold Medal, AAPPO Academic Development Mentorship Scheme (ADMS) 2019 – 2020.
- The AAPPO (Academy of Asia-Pacific Professors of Ophthalmology) is affiliated to APAO, and these Awards recognize significant professional advancements and accomplishments by young clinician-scientists and ophthalmologists in the Asia-Pacific region, in the year 2019 – 2020.
2019/11 Asia-Pacific Vitreo-retina Society (APVRS) Constable Lecture Award, 13th APVRS Congress, Shanghai, 2019.
- The APVRS Constable Lecture is presented annually at the APVRS Congress in honor of Prof Ian Constable. The Lecture is to award up and coming vitreoretinal experts for their exemplary leadership and contribution to the field.
2019/09 Distinguished Young Fellow (2019), Hong Kong Academy of Medicine.
2017/03 APAO Achievement Award 2017, the 32nd APAO Congress, Singapore.
2015/12 Gold Medal, Best Original Research of Trainee 2015, Hong Kong Academy of Medicine, Hong Kong.
2015/07 Winner of Global Research Award, 2015 Global Ophthalmology Awards Program (GOAP), From Bayer, Germany.
- Genomic studies and gene mapping of retina diseases, myopia, and glaucoma
- Genetics of myopia progression in children
- Clinical genetics of inherited retinal dystrophies and optic neuropathies
- Pharmacogenetics of age-related macular degeneration
- Molecular genetics and epi-genetics of diabetic retinopathy, retinitis pigmentosa, uveitis, cornea dystrophies, keratoconus, and hereditary optical neuropathies
- Genetic prediction models for various eye diseases
- Genetic profiling of quantitative traits in children
- Investigations and territory-wide screening for eye diseases in children
|Coordinator of the Retina (Medical) Programme||38th APAO Congress (Kuala Lumpur, Malaysia, 23 - 26 February 2023)|
|Abstract Reviewing Committee Member||38th APAO Congress (Kuala Lumpur, Malaysia, 23 - 26 February 2023)|
|Abstract Reviewing Committee Member||15th APVRS Congress (Taipei, 18 - 20 November 2022)|
|Secretary, Scientific Program Organizing Committee||Subspecialty of Retina – Medical (diabetes), Asia-Pacific Academy of Ophthalmology (APAO) 2021 Congress (Virtual)|
|International/Asia-Pacific Coordinator||Subspecialty of Visual Sciences, APAO 2019 Congress|
|Subspecialty Liaison, World Forum for Sight||World Ophthalmology Congress (WOC) 2018|
|Editorial Board Member||Scientific Reports & Asia Pac J Ophthalmol|
|Member||Asia-ARVO 2015 International Advisory Committee|
- Molecular genomics and mechanisms of age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PCV)
- Molecular genomics and mechanisms of primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG)
- Investigations and screening for eye diseases in children (Hong Kong Children Eye Study) & investigation of genetic factors of longitudinal development of ocular parameters in children
- Molecular genetics of complex eye diseases: high myopia, diabetic macular edema, and uveitis
Results of Note
- Prof Chen is actively working on ophthalmic research. His major research interest is ophthalmic genetics, including new gene identification, population genetic association and mutation profiles investigation, genotype-phenotype correlation, genetic prediction model, gene function and disease pathways of major eye diseases, including macular and retinal diseases (e.g., AMD and PCV, diabetic retinopathy, retinitis pigmentosa, etc.), glaucoma, myopia, and corneal dystrophy, etc. He is also working on the genetic profiling of myopia progression in children. Prof Chen and co-workers have identified a large number of new disease genes/loci, new mutations, new association profiles, and biomarkers for major eye diseases.
- Prof Chen is the Principal Investigator (PI) of 7 external competitive research grants, including 1 General Research Fund (GRF) from the Research Grants Council, Hong Kong; 1 Youth Fund of the National Natural Science Foundation of China (NSFC); 4 Health and Medical Research Fund (HMRF) from Health Bureau, Hong Kong; and 1 Research Award from the Global Ophthalmology Awards Program (GOAP) from Bayer, Germany. The total amount of the research funds is over HK$ 5 million.
- Prof Chen has published over 160 papers in SCI international indexed peer-reviewed journals. He is the first or corresponding author of 56 publications. He has co-authored 1 article in JAMA (Impact factor (IF) 157.335), 7 articles in Nature Genetics (Impact factor (IF) 41.307), 1 in Lancet Oncology (IF 54.433), 1 in Lancet Global Health (IF 38.927), 4 in Nature Communication (IF 17.694), 1 in JAMA Network Open (IF 13.353), 1 in Diabetes Care (IF 17.152), 1 in PNAS (IF 12.779), 2 in American Journal of Human Genetics (IF 11.043), 12 in Ophthalmology (IF 14.277), 3 in JAMA Ophthalmology (IF 8.253), 19 in Brit J Ophthalmol (IF 5.908), 5 in American Journal of Ophthalmology (IF 5.488), and 17 in IOVS (IF 4.925).
- The H-Index of Prof Chen is 47 as of February 2023.
- Yam JC, Zhang XJ, Zhang Y, Yip BHK, Tang F, Wong ES, Bui CHT, Kam KW, Ng MPH, Ko ST, Yip WWK, Young AL, Tham CC, Chen LJ, Pang CP. Effect of Low-Concentration Atropine Eyedrops vs Placebo on Myopia Incidence in Children: The LAMP2 Randomized Clinical Trial. JAMA. 2023 Feb 14;329(6):472-481.
- Kam KW, Chee ASH, Zhang Y, Tang RCY, Chan JTC, Zhang XJ, Wang YM, Chan RCF, Chu WK, Ip P, Young AL, Tham CC, Pang CP, Chen LJ#, Yam JC#. Association of Maternal and Paternal Astigmatism With Child Astigmatism in the Hong Kong Children Eye Study. JAMA Netw Open. 2022 Dec 1;5(12):e2247795.
- Lu SY, Zhang XJ, Wang YM, Yuan N, Kam KW, Chan PP, Tam PO, Yip WW, Young AL, Tham CC, Pang CP, Yam JC, Chen LJ#. Association of SIX1-SIX6 polymorphisms with peripapillary retinal nerve fibre layer thickness in children. Br J Ophthalmol. 2022 Jan 11: Online ahead of print.
- Chen ZJ, Lu SY, Rong SS, Ho M, Ng DS, Chen H, Gong B, Yam JC, Young AL, Brelen M, Tham CC, Pang CP, Chen LJ#. Genetic associations of central serous chorioretinopathy: a systematic review and meta-analysis. Br J Ophthalmol. 2021 May 26: doi: 10.1136/bjophthalmol-2021-318953.
- Chen LJ, Li FF, Lu SY, Zhang XJ, Kam KW, Tang SM, Tam PO, Yip WW, Young AL, Tham CC, Pang CP, Yam JC. Association of polymorphisms in ZFHX1B, KCNQ5 and GJD2 with myopia progression and polygenic risk prediction in children. Br J Ophthalmol. 2021 Dec;105(12):1751-1757.
- Li FF, Lu SY, Tang SM, Kam KW, Pancy O S T, Yip WWK, Young AL, Tham CC, Pang CP, Yam JC, Chen LJ#. Association of multiple gene variants with myopia severities and endophenotypes in children. Br J Ophthalmol. 2021 Aug;105(8):1178-1183.
- Tang SM, Li FF, Lu SY, Kam KW, Tam PO, Tham CC, Pang CP, Yam JC, Chen LJ#. Association of the ZC3H11B, ZFHX1B and SNTB1 Genes with Myopia of Different Severities. Br J Ophthalmol. 2020 Oct;104(10):1472-1476.
- Lu SY, Tang SM, Li FF, Kam KW, Pam PO, Yip WK, Young AL, Tham CC, Pang CP, Yam JC, Chen LJ#. Association of WNT7B and RSPO1 with Axial Length in School Children. Invest Ophthalmol Vis Sci. 2020 Aug 3;61(10):11.
- Lu SY, Rong SS, Wu Z, Huang C, Matsushita K, Ng TK, Leung CK, Kawashima R, Usui S, Tam PO, Tsujikawa M, Young AL, Zhang M, Wiggs J, Nishida K, Tham CC, Pang CP, Chen LJ#. Association of the CAV1-CAV2 locus with Normal Tension Glaucoma in Chinese and Japanese. Clin Exp Ophthalmol. 2020 Jul;48(5):658-665.
- Chen ZJ, Ma L, Brelen ME, Chen H, Tsujikawa M, Lai TY, Ho M, Sayanagi K, Hara C, Hashida N, Tam PO, Young AL, Nishida K, Tham CC, Pang CP, Chen LJ#. Identification of TIE2 as a susceptibility gene for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. Br J Ophthalmol. 2020 Mar 9. [Epub ahead of print]
- Ma L, Ng TK, Chen H, Brelén ME, Lai TYY, Ho M, Tam POS, Young AL, Chen W, Tham CC, Pang CP, Chen LJ#. Identification and characterization of a novel promoter variant in placental growth factor for neovascular age-related macular degeneration. Exp Eye Res. 2019 Aug 1;187:107748.
- Wang YM, Ma L, Lu SY, Chan TCY, Yam JCS, Tang SM, Kam KW, Tam POS, Tham CC, Young AL, Jhanji V, Pang CP, Chen LJ#. Analysis of multiple genetic loci reveals MPDZ-NF1B rs1324183 as a putative genetic marker for keratoconus. Br J Ophthalmol. 2018 Dec;102(12):1736-1741.
- Tang SM, Ma L, Lu SY, Wang YM, Kam KW, Tam POS, Young AL, Pang CP, Yam JCS, Chen LJ#. Association of the PAX6 gene with extreme myopia rather than lower grade myopias. Br J Ophthalmol. 2018 Apr;102(4):570-574.
- Tang FY, Ma L, Tam POS, Pang CP, Tham CCY, Chen LJ#. Genetic Association of the PARL-ABCC5-HTR3D-HTR3C Locus with Primary Angle-Closure Glaucoma in Chinese. Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4104-4109.
- Ma L, Brelen ME, Tsujikawa M, Chen H, Chu WK, Lai TY, Ng DS, Sayanagi K, Hara C, Hashida N, Chan VC, Tam PO, Young AL, Chen W, Nishida K, Pang CP, Chen LJ#. Identification of ANGPT2 as a New Gene for Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in the Chinese and Japanese Populations. Invest Ophthalmol Vis Sci. 2017 Feb 1; 58(2):1076-1083.
- Ma L, Liu K, Tsujikawa M, Chen H, Brelen ME, Chan VC, Lai TY, Sayanagi K, Hara C, Hashida N, Tam PO, Young AL, Chen W, Nishida K, Pang CP, Chen LJ#. Association of ABCG1 with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Chinese and Japanese. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5758-5763.
- Huang L, Zhang H, Cheng CY, Wen F, Tam PO, Zhao P, Chen H, Li Z, Chen LJ, Tai Z, Yamashiro K, Deng S, Zhu X, Chen W, Cai L, Lu F, Li Y, Cheung CG, Shi Y, Miyake M, Lin Y, Gong B, Liu X, Sim KS, Yang J, Mori K, Zhang X, Cackett PD, Tsujikawa M, Nishida K, Hao F, Ma S, Lin H, Cheng J, Fei P, Lai TY, Tang S, Laude A, Inoue S, Yeo IY, Sakurada Y, Zhou Y, Iijima H, Honda S, Lei C, Zhang L, Zheng H, Jiang D, Zhu X, Wong TY, Khor CC, Pang CP, Yoshimura N, Yang Z. A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy. Nat Genet. 2016 Jun;48(6):640-7.
- Chen LJ, Ma L, Chu WK, Lai TY, Chen H, Brelén ME, Rong SS, Young AL, Tam PO, Zhang M, Pang CP. Identification of PGF as a New Gene for Neovascular Age-Related Macular Degeneration in a Chinese Population. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):1714-1720.
- Khor CC*, Do T*, Jia H*, Nakano M*, George R*, Abu-Amero K*, Duvesh R*, Chen LJ*, Li Z, Nongpiur ME, Perera SA, Qiao C, Wong HT, Sakai H, Barbosa de Melo M, Lee MC, Chan AS, Azhany Y, Dao TL, Ikeda Y, Perez-Grossmann RA, Zarnowski T, Day AC, Jonas JB, Tam PO, Tran TA, Ayub H, Akhtar F, Micheal S, Chew PT, Aljasim LA, Dada T, Luu TT, Awadalla MS, Kitnarong N, Wanichwecharungruang B, Aung YY, Mohamed-Noor J, Vijayan S, Sarangapani S, Husain R, Jap A, Baskaran M, Goh D, Su DH, Wang H, Yong VK, Yip LW, Trinh TB, Makornwattana M, Nguyen TT, Leuenberger EU, Park KH, Wiyogo WA, Kumar RS, Tello C, Kurimoto Y, Thapa SS, Pathanapitoon K, Salmon JF, Sohn YH, Fea A, Ozaki M, Lai JS, Tantisevi V, Khaing CC, Mizoguchi T, Nakano S, Kim CY, Tang G, Fan S, Wu R, Meng H, Nguyen TT, Tran TD, Ueno M, Martinez JM, Ramli N, Aung YM, Reyes RD, Vernon SA, Fang SK, Xie Z, Chen XY, Foo JN, Sim KS, Wong TT, Quek DT, Venkatesh R, Kavitha S, Krishnadas SR, Soumittra N, Shantha B, Lim BA, Ogle J, de Vasconcellos JP, Costa VP, Abe RY, de Souza BB, Sng CC, Aquino MC, Kosior-Jarecka E, Fong GB, Tamanaja VC, Fujita R, Jiang Y, Waseem N, Low S, Pham HN, Al-Shahwan S, Craven ER, Khan MI, Dada R, Mohanty K, Faiq MA, Hewitt AW, Burdon KP, Gan EH, Prutthipongsit A, Patthanathamrongkasem T, Catacutan MA, Felarca IR, Liao CS, Rusmayani E, Istiantoro VW, Consolandi G, Pignata G, Lavia C, Rojanapongpun P, Mangkornkanokpong L, Chansangpetch S, Chan JC, Choy BN, Shum JW, Than HM, Oo KT, Han AT, Yong VH, Ng XY, Goh SR, Chong YF, Hibberd ML, Seielstad M, Png E, Dunstan SJ, Chau NV, Bei J, Zeng YX, Karkey A, Basnyat B, Pasutto F, Paoli D, Frezzotti P, Wang JJ, Mitchell P, Fingert JH, Allingham RR, Hauser MA, Lim ST, Chew SH, Ebstein RP, Sakuntabhai A, Park KH, Ahn J, Boland G, Snippe H, Stead R, Quino R, Zaw SN, Lukasik U, Shetty R, Zahari M, Bae HW, Oo NL, Kubota T, Manassakorn A, Ho WL, Dallorto L, Hwang YH, Kiire CA, Kuroda M, Djamal ZE, Peregrino JI, Ghosh A, Jeoung JW, Hoan TS, Srisamran N, Sandragasu T, Set SH, Doan VH, Bhattacharya SS, Ho CL, Tan DT, Sihota R, Loon SC, Mori K, Kinoshita S, Hollander AI, Qamar R, Wang YX, Teo YY, Tai ES, Hartleben-Matkin C, Lozano-Giral D, Saw SM, Cheng CY, Zenteno JC, Pang CP, Bui HT, Hee O, Craig JE, Edward DP, Yonahara M, Neto JM, Guevara-Fujita ML, Xu L, Ritch R, Liza-Sharmini AT, Wong TY, Al-Obeidan S, Do NH, Sundaresan P, Tham CC, Foster PJ, Vijaya L, Tashiro K, Vithana EN, Wang N, Aung T. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nat Genet. 2016 May;48(5):556-62.
- Rong SS, Tang FY, Chu WK, Ma L, Yam JC, Tang SM, Li J, Gu H, Young AL, Tham CC, Pang CP, Chen LJ#. Genetic Associations of Primary Angle-Closure Disease: A Systematic Review and Meta-analysis. Ophthalmology. 2016 Jun;123(6):1211-21.
- Ma L, Li Z, Liu K, Rong SS, Young AL. Kumaramanickavel G, Pang CP, Chen H, Chen LJ#. Association of genetic variants with polypoidal choroidal vasculopathy: a systemic review and updated meta-analysis. Ophthalmology. 2015 Sep;122(9):1854-65.19.
- Cheng CY*, Yamashiro K*, Chen LJ*, Ahn J, Huang L, Huang L, Cheung CM, Miyake M, Cackett PD, Yeo IY, Laude A, Mathur R, Pang J, Sim KS, Koh AH, Chen P, Lee SY, Wong D, Chan CM, Loh BK, Sun Y, Davila S, Nakata I, Nakanishi H, Akagi-Kurashige Y, Gotoh N, Tsujikawa A, Matsuda F, Mori K, Yoneya S, Sakurada Y, Iijima H, Iida T, Honda S, Lai TY, Tam PO, Chen H, Tang S, Ding X, Wen F, Lu F, Zhang X, Shi Y, Zhao P, Zhao B, Sang J, Gong B, Dorajoo R, Yuan JM, Koh WP, van Dam RM, Friedlander Y, Lin Y, Hibberd ML, Foo JN, Wang N, Wong CH, Tan GS, Park SJ, Bhargava M, Gopal L, Naing T, Liao J, Ong PG, Mitchell P, Zhou P, Xie X, Liang J, Mei J, Jin X, Saw SM, Ozaki M, Mizoguchi T, Kurimoto Y, Woo SJ, Chung H, Yu HG, Shin JY, Park DH, Kim IT, Chang W, Sagong M, Lee SJ, Kim HW, Lee JE, Li Y, Liu J, Teo YY, Heng CK, Lim TH, Yang SK, Song K, Vithana EN, Aung T, Bei JX, Zeng YX, Tai ES, Li XX, Yang Z, Park KH, Pang CP, Yoshimura N, Wong TY, Khor CC. New loci and coding variants confer risk for age-related macular degeneration in East Asians. Nat Commun. 2015 Jan 28; 6:6063.
- Liu K*, Chen LJ*, Lai TY, Tam PO, Ho M, Chiang SW, Liu DT, Young AL, Yang Z, Pang CP. Genes in the High-Density Lipoprotein Metabolic Pathway in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy. Ophthalmology. 2014 Apr; 121(4):911-6.
( * co-first author ; # corresponding author )
In the Media
|30/05/2023||CUHK study reveals 1 in 5 Hong Kong children have moderate to severe astigmatism
Strong parental astigmatism influence observed