Prof LEUNG Kai Shun Christopher 梁啟信教授

Prof LEUNG Kai Shun Christopher

Professor

MBChB(CUHK), MD (CUHK), BMedSc, MSc (Lond), FCOphth (HK), FHKAM

Contact :

(852) 3943 5846

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(852) 3943 5886

Academic Appointments

  • Professor, Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong
  • Associate Director, CUHK Ophthalmic Research Centre
  • Adjunct Professor, Division of Biomedical Engineering, The Hong Kong University of Science and Technology
  • Honorary Consultant, Hong Kong Eye Hospital
  • Honorary Consultant, New Territories East Cluster Ophthalmology Service
  • Honorary Consultant, Department of Ophthalmology, Caritas Medical Centre

Biography

Prof Christopher Leung is a clinician-scientist with research focus on glaucoma investigation and management. He was awarded the Chevening Postgraduate Scholarship in 1996 to study molecular medicine at the Imperial College London and the Croucher Foundation Fellowship in 2006 to complete a clinical and research fellowship in glaucoma at the Hamilton Glaucoma Center, the University of California, San Diego (UCSD).

Prof Leung is Section Editor of British Journal of Ophthalmology, Contributing Editor of International Glaucoma Review, Editorial Board Member of Ophthalmic Epidemiology, Translational Vision Science & Technology, and Ocular Surgery News (Asia Pacific Edition), and reviewer of over 30 peer-reviewed scientific journals.

Prof Leung has received a number of research and service awards including the National Best Paper on Prevention of Blindness in the World Ophthalmology Congress (2006), UCSD Schanzlin Research Award (2007), American Academy of Ophthalmology Achievement Award (2008), Asia Pacific Academy of Ophthalmology Nakajima Award (2010), Asia Pacific Academy of Ophthalmology Achievement Award (2010), Association for Research in Vision and Ophthalmology Alcon Clinician-Scientist Research Award (2010), Asia Pacific Joint Glaucoma Congress Young Scientist Award (2010), World Glaucoma Congress Science Award (2009 and 2011), Asia-Pacific Glaucoma Society Young Investigator Award (2012), American Academy of Ophthalmology Secretariat Award (2012), Asia Pacific Academy of Ophthalmology Distinguished Service Award (2014), and American Academy of Ophthalmology Senior Achievement Award (2015).

Research Areas

  1. Application of advanced imaging technologies for early detection and monitoring of glaucoma.
  2. Investigation of new laser procedures and surgical devices for lowering the intraocular pressure
  3. Development of new therapies to protect and regenerate retinal ganglion cells in glaucoma and other optic neuropathies.
Scientific Program Coordinator World Ophthalmology Congress 2018 (Spain)
Co-Chair, Scientific Program Committee The 33rd Asia-Pacific Academy of Ophthalmology Congress 201 8 (Hong Kong)
Scientific Program Committee World Glaucoma Congress 2017 ( Finland)
Faculty Member ARVO-Asia Translational Vision Summit 2017 (Australia)
Section Head (Glaucoma) The Asia-Australia Controversies in Ophthalmology Congress 2016 (Thailand)
Scientific Program Coordinator World Ophthalmology Congress 2016 (Mexico)
Scientific Program Coordinator The 31st Asia-Pacific Academy of Ophthalmology Congress 2016 (Taiwan)

Research Programmes

  1. Design and develop new applications of optical coherence tomography for early diagnosis and monitoring of glaucoma.
  2. Devise virtual reality platforms for evaluation of visual disability and visual performance.
  3. Develop algorithms for three-dimensional analysis of the anterior chamber angle for detection of patients with angle closure diseases.
  4. Evaluate new laser and surgical techniques for lowering the intraocular pressure in the management of glaucoma.
  5. Investigate mechanisms and therapies for neuroprotection and optic nerve regeneration.

Accomplishments

  1. We have awarded major competitive research grants from Hong Kong Research Grants Council, HKSAR Food and Health Bureau, and Information Technology Fund for clinical trials investigating new treatment paradigms for glaucoma and development of virtual reality devices for evaluation of visual disability.
  • Measurement of the Rates of Retinal Nerve Fiber Layer Thinning to Guide Management of Myopic Glaucoma Patients (GRF 2017) (HKD 661,844).
  • Progressive Retinal Nerve Fiber Layer Thinning as a Biomarker to Guide Intraocular Pressure Lowering Treatment in Ocular Hypertensives (GRF 2016) (HKD1,174,782).
  • Progressive Lamina Cribrosa Deformation – A Biomarker for Fast Progressors in Glaucoma? (GRF 2015) (HKD858,688).
  • Impact of PTEN/SOCS3 Deletion on Dendritic regeneration: A Time-lapse in vivo Imaging Study (GRF 2014) (HKD533,782).
  • Evaluation of Visual Disability in a Virtual Reality Environment (ITF 2016) (HKD1,396,456).
  • A Randomized Controlled Trial Comparing the Efficacy and Safety between Pattern Laser Trabeculoplasty and Selective Laser Trabeculoplasty. (HMRF 2015) (HKD990,518).
  • Evaluation of Visual Disability in a Virtual Reality Environment. Technology Start-up Support Scheme for Universities 2016 (HKD 100,000); 2017 (HKD 300,000).
  • Evaluation of Visual Disability in a Virtual Reality Environment. Business and Technology Development Fund 2016 (HKD 200,000).
  1. Three patents have been filed with one (Trend-based Progression Analysis (TPA) for detection of progressive retinal nerve fiber layer) licensed by Carl Zeiss Meditec in 2016 for clinical application in the global market.
  • Detection of disease-related retinal nerve fiber layer thinning (U.S. Application No. 13/898,176).
  • Induction of chronic elevation of intraocular pressure with intracameral cross-linking hydrogel (U.S. Application No. 61/967,094).
  • Visual Disability Detection System Using Virtual Reality (U.S. Application No. 15/466,348).
  1. We have received research support from and collaborated with major developers and manufacturers of advanced ophthalmic instruments including Carl Zeiss Meditec (Dublin, CA, USA), Topcon (Tokyo, Japan), Heidelberg Engineering (Heidelberg, Germany), Tomey (Nagoya, Japan), and Glaukos (San Clemente, CA, USA) for testing and development of new devices for investigation and treatment of eye diseases.

Representative Publications:

  1. Lin C, Mak H, Yu M, Leung CK. Trend-Based Progression Analysis for Examination of the Topography of Rates of Retinal Nerve Fiber Layer Thinning in Glaucoma. JAMA Ophthalmol. 2017;135:189-195.
  2. Henrich-Noack P, Sergeeva EG, Eber T, You Q, Voigt N, Köhler J, Wagner S, Lazik S, Mawrin C, Xu G, Biswas S, Sabel BA, Leung CK. Electrical brain stimulation induces dendritic stripping but improves survival of silent neurons after optic nerve damage. Sci Rep. 2017;7:627.
  3. Wu Z, Lin C, Crowther M, Mak H, Yu M, Leung CK. Impact of Rates of Change of Lamina Cribrosa and Optic Nerve Head Surface Depths on Visual Field Progression in Glaucoma. Invest Ophthalmol Vis Sci. 2017;58:1825-1833.
  4. Yu M, Lin C, Weinreb RN, Lai G, Chiu V, Leung CK. Risk of Visual Field Progression in Glaucoma Patients with Progressive Retinal Nerve Fiber Layer Thinning: A 5-Year Prospective Study. Ophthalmology. 2016;123:1201-10.
  5. Biswas S, Lin C, Leung CK. Evaluation of a Myopic Normative Database for Analysis of Retinal Nerve Fiber Layer Thickness. JAMA Ophthalmol. 2016;134:1032-9.
  6. Wu Z, Xu G, Weinreb RN, Yu M, Leung CK. Optic nerve head deformation in glaucoma: a prospective analysis of optic nerve head surface and lamina cribrosa surface displacement. Ophthalmology. 2015; 122:1317-29.
  7. Xu G, Weinreb RN, Leung CK. Optic Nerve Head Deformation in Glaucoma: The Temporal Relationship between Optic Nerve Head Surface Depression and Retinal Nerve Fiber Layer Thinning. Ophthalmology. 2014;121:2362-70.
  8. Liu S, Yu M, Weinreb RN, Lai G, Lam DS, Leung CK. Frequency-doubling technology perimetry for detection of the development of visual field defects in glaucoma suspect eyes: a prospective study. JAMA Ophthalmol. 2014;132:77-83.
  9. Narayanaswamy A, Leung CK, Istiantoro DV, Perera SA, Ho CL, Nongpiur ME, Baskaran M, Htoon HM, Wong TT, Goh D, Su DH, Belkin M, Aung T. Efficacy of Selective Laser Trabeculoplasty in Primary Angle-Closure Glaucoma: A Randomized Clinical Trial. JAMA Ophthalmol. 2015;133:206-12.
  10. 10. Lindsey JD, Duong-Polk KX, Hammond D, Leung CK, Weinreb RN. Protection of injured retinal ganglion cell dendrites and unfolded protein response resolution after long-term dietary resveratrol. Neurobiol Aging. 2015;36:1969-81.

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