Staff Profile – Dr CHU Wai Kit 朱偉傑助理教授 (Copy)

Chu

Dr CHU Wai Kit 朱偉傑助理教授

BSc, MPhil (CUHK), DPhil (Oxon)

Assistant Professor of Ophthalmology and Visual Sciences, Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong
Associate Head, Graduate Division, Department of Ophthalmology andVisual Sciences, The Chinese University of Hong Kong
Honorary Associate Professor, Shantou University Medical College

Office tel.: (852) 3943 5860
Fax no.: (852) 2715 9490
e-mail: waikit@cuhk.edu.hk

Biography

The academic interests of Dr Chu focus in gene functions in various eye diseases as well as developing novel treatments for these diseases. Dr Chu’s earlier work established molecular roles for helicases BLM and FBH1 in preserving genome stability. Dr Chu’s work is supported by the National Natural Science Foundation of China (NSFC), the Innovation and Technology Fund (ITF) of Hong Kong and several CUHK internal grants.

Dr Chu is currently a journal editor of Hong Kong Journal of Ophthalmology. He was also a former journal editor of Disease Markers. He also serves as reviewers of multiple journals such as Scientific Reports, Oncotarget, British Journal of Ophthalmology, Experimental Eye Research and American Journal of Ophthalmology Case Reports.

The academic interests of Dr Chu focus in gene functions in various eye diseases as well as developing novel treatments for these diseases. Dr Chu’s earlier work established molecular roles for helicases BLM and FBH1 in preserving genome stability.

Dr Chu served as the international advisory committee of the ARVO-Asia Annual Meeting in 2017. Dr Chu is also an active member of Asia Pacific Academy of Ophthalmology (APAO) and served as the Secretary of the Visual Sciences Program of the 31st and 33rd APAO Annual Congress in 2016 and 2018 respectively.

Research Interests

  1. Ocular inflammation: Uveitis is a group of diseases characterized by intraocular inflammation. I am currently developing novel treatments for uveitis.
  2. Thyroid-associated orbitopathy (TAO): Patients with TAO have expanded fibrotic orbital tissues. If left untreated, TAO would lead to double vision and optic nerve compression. I am studying the disease mechanisms of TAO.
  3. Mitotic defects in eye diseases: Mitosis is a cell cycle stage that chromosomes in a nucleus are separated into two daughter nuclei. Defective mitosis would lead to genome instability. I am studying how mitotic defects lead to eye diseases.
  4. Retinoblastoma: Retinoblastoma cells have lower levels of apoptotic cell death. I am exploring pathways that could induce apoptosis to restrict the uncontrolled cell growth in retinoblastoma.
  5. Pterygium: Pterygium is an abnormally growing tissue invading onto the cornea. I am investigating the pathophysiological mechanisms of pterygium development.
  6. Glaucoma: Elevated intraocular pressure (IOP) is a major risk factor for glaucoma. I am studying the causes and consequences of the IOP elevation.

Representative Publications

  1.  Cao, D., Ng, T. K., Yip, Y. W. Y., Young, A. L., Pang, C. P., Chu, W. K. and Jhanji, V. (2018) p53 inhibition by MDM2 in human pterygium. Experimental Eye Research, 175, 142.
  2.  Zhang, B. N., Venegas, A. B., Hickson, I. D. and Chu, W. K. (2018) DNA replication stress and its impact on chromosome segregation and tumorigenesis. Seminars in Cancer Biology.
  3.  Wong, J. S. C., Chu, W. K., Li, B. F., Pang, C. P. and Chong, K. K. L. (2018) Depot-specific characteristics of adipose tissue-derived stromal cells in thyroid-associated orbitopathy. British Journal of Ophthalmology.
  4. Cao, D., Chu, W. K., Ng, T. K., Yip, Y. W. Y., Young, A. L., Pang, C. P. and Jhanji, V. (2018) Cellular Proliferation and Migration of Human Pterygium Cells: Mitomycin Versus Small-Molecule Inhibitors. Cornea, 37, 760.
  5. Li, J., Ren, J., Yip, Y. W. Y., Zhang, X., Chu, K. O., Ng, T. K., Chan, S. O., Pang, C. P. and Chu, W. K. (2017) Quantitative Characterization of Autoimmune Uveoretinitis in an Experimental Mouse Model. Investigative Ophthalmology & Visual Science, 58, 4193.
  6. Chu, W. K., Law, K. S., Chan, S. O., Yam, J. C. S., Chen, L. J., Zhang, H., Cheung, H. S., Block, N. L., Schally, A. V. and Pang, C. P. (2016) Antagonists of growth hormone-releasing hormone receptor induce apoptosis specifically in retinoblastoma cells. Proceedings of the National Academy of Sciences of the United States of America, 113, 14396.
  7. Chu, W.K., Payne, M.J., Beli, P., Hanada, K., Choudhary, C. and Hickson, I.D. (2015) FBH1 influences replication-associated homologous recombination through ubiquitylation of RAD51. Nature Communications, 6, 5931.
  8. Ying, S., Minocherhomji, S., Chan, K.L., Palmai-Pallag, T., Chu, W.K., Wass, T., Mankouri, H.W., Liu, Y. and Hickson, I.D. (2013) MUS81 promotes common fragile site expression. Nature Cell Biology, 15, 1001.
  9. Chu, W.K., Hanada, K., Kanaar, R. and Hickson, I.D. (2010) BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells. Oncogene, 29, 4705-14.
  10. Chu, W.K. and Hickson, I.D. (2009) RecQ helicases: multifunctional genome caretakers. Nature Reviews Cancer, 9, 644-654.