microRNA research at CUHK Ophthalmic Research Centre
microRNA research is an outstanding research area in the CUHK Ophthalmic Research Centre (CORE). microRNAs belong to a class of epigenetic regulatory elements for RNA interference (The Nobel Prize in Physiology or Medicine for 2006), which negatively regulate the translation of protein-coding genes. We not only study the microRNA regulatory mechanisms for eye diseases, but also provide services of microRNA profiling for our collaborators over the world.
Recently, in collaboration with the University of Miami, we delineated the microRNA regulatory mechanism of cardiomyogenic differentiation of periodontal ligament-derived stem cells by dynamic tensile strain . We found that 39 microRNAs show significant changes, and 16 of the differentially expressed microRNAs are related to heart development. This study demonstrates the potential of stem cells for the treatment of myocardial infarction.
1. Pelaez D, et al. Cardiomyogenesis of periodontal ligament-derived stem cells by dynamic tensile strain. Cell Tissue Res, 2016.
To view the full article: http://link.springer.com/article/10.1007%2Fs00441-016-2503-x