Ophthalmic Research – ZHANG Xiaoyu

ZHANG Xiaoyu

 

Research areas:

(1) Biological effects and mechanisms of oxidative stress on retinal pigment epithelial cell dysfunction
(2) Biological effects and mechanisms of cigarette smoking on retinal pigment epithelial cell dysfunction

 

Supervisor:

Dr NG Tsz Kin, Michael

 

Research Highlights:

(1) Studying the biological effects and mechanisms of oxidative stress on retinal pigment epithelial cell dysfunction
Retinal pigment epithelial (RPE) cell degeneration is the pathological cause of age-related macular (AMD) degeneration. Oxidative stress is an important factor contributing to the pathogenesis of AMD. We are investigating the biological effects of chronic oxidative stress on RPE cell functions as well as its underlying mechanisms.
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Figure 1. Chronic oxidative stress weakens RPE cell integrity as indicated by the immunofluorescence analysis of tight junction protein (ZO-1).

 

(2) Studying the biological effects and mechanisms of cigarette smoking on retinal pigment epithelial cell dysfunction
Retinal pigment epithelial (RPE) cell degeneration is the pathological cause of age-related macular (AMD) degeneration. Cigarette smoking is a consistent risk factor for AMD development. Nicotine is one of the major constituents in cigarette smoke and cigarette replacements, including electronic cigarette and nicotine patches. We are investigating the biological effects of chronic exposure of nicotine on RPE cell functions and its underlying mechanisms.
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Figure 2. Nicotine affects the angiogenic factor expression in RPE cells as shown by the multiplex array.