Ophthalmic Research – Janice WONG

WONG Siu Chong Janice



  • MSc, Ophthalmology and Visual Sciences, The Chinese University of Hong Kong
  • BSc, Biology, The Chinese University of Hong Kong

Research areas:

  1. Role of adipose tissue-derived stem / stromal cells (ADSC) in the pathogenesis of thyroid-associated orbitopathy (TAO)
  2. Effect of TAO patients’ plasma on ADSC



Research Highlights:

(1) Studying site-specific properties of ADSC in key pathways in TAO

Patients with TAO have expanded and fibrotic orbital tissues, contributing to exophthalmos, diplopia and optic nerve compression due to immune-driven, enhanced adipogenesis and myofibrogenesis (fibrosis). ADSC were isolated from patients’ orbital adipose tissues and used to study these two pathways:

Pathway 1. Induction of orbital ADSC to Adipogenesis – ADSC were induced to adipocytes, intracellular neutral lipid, identified with Nile Red stain (green)


Pathway 2. Induction of isolated ADSC to Myofibrogenesis (fibrosis) – ADSC were induced to myofibroblasts, identified with alpha-smooth muscle actin (a-SMA) (green).


(2) Studying interactions between plasma of TAO patients and ADSC

We collect plasma from TAO patients and study their effects on the ADSC in terms of the two pathways above – adipogenesis and myofibrogenesis.