Ophthalmic Research – TANG Fangyao

TANG Fangyao

 

Qualification:

  • MPhil, Ophthalmology and Visual Sciences, The Chinese University of Hong Kong

Research Areas:

  1. Risk assessment for vision threatening diabetic retinopathy using novel retinal imaging
  2. Genetic association of single nucleotide polymorphisms and primary angle-closure glaucoma

Supervisor:

Publications:

  1. Rong SS, Tang FY, Chu WK, Ma L, Yam JC, Tang SM, Li J, Gu H, Young AL, Tham CC, Pang CP, Chen LJ. Genetic Associations of Primary Angle-Closure Disease: A Systematic Review and Meta-analysis. Ophthalmology. 2016 Feb 4. pii: S0161-6420(15)01530-4.
  2. Ma L, Tang FY, Chu WK, Young AL, Brelen ME, Pang CP, Chen LJ. Association of toll-like receptor 3 polymorphism rs3775291 with age-related macular degeneration: a systematic review and meta-analysis. Sci Rep. 2016 Jan 22; 6:19718.
  3. Tan S, Yu M, Baig N, Chan PP, Tang FY, Tham CC. Circadian Intraocular Pressure Fluctuation and Disease Progression in Primary Angle Closure Glaucoma. Invest Ophthalmol Vis Sci. 2015 Jul 1; 56(8):4994-5005.
  4. Chen X, Rong SS, Xu Q, Tang FY, Liu Y, Gu H, Tam PO, Chen LJ, Brelén ME, Pang CP, Zhao C. Diabetes mellitus and risk of age-related macular degeneration: a systematic review and meta-analysis. PLoS One. 2014 Sep 19; 9(9):e108196.

 

Research Highlights:

(1) Risk assessment for vision threatening diabetic retinopathy using novel retinal imaging

Diabetic retinopathy (DR) is a common complication of diabetes mellitus. It is a leading global cause of preventable blindness. Recently, DR examined by optical coherence angiography (OCT-A) have been reported. However, automated method for quantitative assessment of retinal capillary network is still lacking. We developed a prototype automated analysis system to quantify and measure retinal capillary network from OCT-angiograms, and examining the associations of the OCT-A measures with different DR severity and hyperglycemia in a cohort with diabetes.

 

Research-Highlight-TANG-Fangyao-1

Figure 1. Imaging of retinal capillary network with swept-source OCTA: A custom MATLAB program for analyzing OCT-angiograms at (A-D) superficial capillary plexus. Measurement includes FAZ area (blue) and total capillary non-perfusion area (red).

 

(2) Genetic association analysis of ABCC5 locus and primary angle-closure glaucoma

Primary angle-closure glaucoma (PACG) is an irreversible blindness worldwide. It is a multifactorial disease, and genetic basis of PACG has been identified previously. In this study we genotyped 30 haplotype-tagging single nucleotide polymorphisms (SNPs) in ABCC5 locus, and analyzed association of their frequencies and PACG. We identified 2 new synonymous coding SNPs, namely rs9393** and rs11327** significantly associated with PACG (Table 1), and specifically associated with chronic form of the disease (Table 2). The discovery of coding SNPs within ABCC5, which was found to be associated with ACD, are in keeping with the anterior segment anatomical risk factors of susceptibility to PACG.

 

Table 1. Allelic association of SNPs in PARL-ABCC5-HTR3D-HTR3C region with PACG

Research-Highlight-TANG-Fangyao-2

 

Table 2. Allelic association of SNPs in PARL-ABCC5-HTR3D-HTR3C region with CACG

Research-Highlight-TANG-Fangyao-3