Ophthalmic Research – LIN Chen

LIN Chen



  • Master, Ophthalmology, Fujian Medical University
  • Bachelor, Clinical Medicine, Fujian Medical University

Past Experiences:

  • Attending Eye Doctor, People’s Hospital of Fujian Province
  • University Teacher, Ophthalmology, People’s Hospital of Fujian Province
  • Eye Doctor, Fuzhou Southeast Eye Hospital

Research Areas:

  1. Topographical analysis of the retinal nerve fiber layer for detection of glaucoma and its progression.



  1. Marco Yu, Chen Lin, Weinreb, et al. Risk of Visual Field Progression in Glaucoma Patients with Progressive Retinal Nerve Fiber Layer Thinning – A 5-year Prospective Study. Ophthalmology. 2016, In press.


Research Highlights:

(1) Trend-based Progression Analysis (TPA)

Early detection of disease deterioration behavior is critical to the formulation of treatment plan for glaucoma patients. While measurements of retinal nerve fiber layer (RNFL) have been used to monitor glaucoma progression in clinical practice by both event and trend analyses, little is known about the optimal strategy for detection of change. In our study, we investigated the performance of Guided Progression Analysis (GPA) and Trend-based Progression Analysis (TPA) for detection of progressive RNFL thinning measured with a spectral-domain optical coherence tomography (OCT). We found that progressive RNFL thinning determined by GPA and TPA is highly predictive of development of functional decline in patients with glaucoma.

Figure 1. Rate of change of RNFL thickness map illustrating the rates of progressive RNFL thinning in a glaucomatous eye followed for 3 years.