Ophthalmic Research – LI Jian

LI Jian



  • Master, Ophthalmology and Optometry, Wenzhou Medical University

Research Areas:

  1. Paediatric eye diseases
  2. Treatments of autoimmune-related uveitis



  1. Li, J. and Chu, W.K. (2016) Experimental autoimmune uveoretinitis model and intraocular inflammation. Hong Kong Journal of Ophthalmology. (In press).
  2. Rong, S.S., Tang, F.Y., Chu, W.K., Ma, L., Yam, J. C. S., Tang, S. M., Li, J., Gu, H., Young, A. L., Tham, C. C., Pang, C. P. and Chen, L.J. (2016) Genetic associations of primary angle-closure phenotypes: a systematic review and meta-analysis. Ophthalmology. S0161:1530-1534.


Research Highlights:

(1) Paediatric eye diseases

We are conducting a comprehensive eye examination program for children in Hong Kong. Primary 1- Primary 3 children are invited to join this program. This is a 3-year program, where all participants will have one comprehensive and free eye check-up annually. Children requiring ophthalmic attention will be promptly referred for follow-up and early treatment. Through this 3-year program, all participants will have their ocular health development in these critical ages closely monitored. Parents are also invited to fill up two sets of questionnaires on children’s diet and daily activity pattern, in order to identify the risk factors for developing the serious eye disease. Furthermore, both parents of each child participant are also invited to take part in this program, where free and fundamental eye examination will be provided.


(2) Treatments of autoimmune-related uveitis

Intraocular inflammation is one of the leading causes of visual damages. Human uveitis is a group of diseases characterized by inflammatory lesions of intraocular structures. Many cases are idiopathic, which could be classified as infectious uveitis and autoimmune-related uveitis. Comparing to the infectious uveitis, our knowledge and treatment options on autoimmune-related uveitis are still very limited. Therefore, for development of effective therapeutic strategies and agents, it is essential to explore the basic mechanisms and pathogenesis of autoimmune ocular diseases. Experimental autoimmune uveoretinitis (EAU) animal model has been widely used to study the physiopathogenesis of autoimmune inflammation. We are currently developing novel treatments for autoimmune-related uveitis by using the EAU animal model.

Figure 1. Histopathology of experimental autoimmune uveoretinitis in (A and B) C57BL/6J mouse (H&E stain, ×40) and (C) normal mouse (H&E stain, ×20). Cellular infiltrates in vitreous and retina (arrows) and retinal folds (asterisks) are shown.