- MMed, Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University
- Intervention for myopia progression
- The function of Retinoblastoma protein
(1) Intervention for myopia progression
Myopia is a prevalent ocular disease in Hong Kong. The prevalence of myopia in preschool children is on the rise, increasing significantly from 2.3% to 6.3% over a ten-year period. Myopia is associated with many sight-threatening complications such as pre-senile cataract, glaucoma, retinal detachment, and characteristic degenerative changes of the sclera, retinal pigment epithelium and choroid. Different interventions have been attempted to reduce the myopic progression, which includes optical under-correction with spectacles, bifocals lenses, progressive lenses and contact lenses. However, results from these studies are conflicting, and no strong evidence in reducing myopia progression can be shown in these measures. This study is to evaluate the intervention in regarding myopia progression.
(2) The function of Retinoblastoma protein
Retinoblastoma, an intraocular tumour, is caused by mutations in the RB1 gene. RB1 has been established as an important regulator of the cell cycle checkpoint, which safeguards the genome stability and cell growth. Recently, additional functions of RB1 have been identified. We are characterizing these novel functions of RB1 to have better understandings of retinoblastoma.