Research Themes and Projects

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Research Themes & Projects

 

Clinical Research

Clinical Studies in Glaucoma, Lens Surgery 

  • Primary angle closure glaucoma (PACG) and normal tension glaucoma (NTG) – patterns and risk factors of disease progression
  • The roles of lens extractionwith laser and/or surgical glaucoma interventions, in glaucoma eyes
  • The clinical efficacy and safety of glaucoma interventions, including laser peripheral iridotomy and iridoplasty, trabeculectomy (penetrating, non-penetrating, carbon dioxide laser-assisted), goniosynechialysis (GSL), glaucoma implant surgery, laser cyclodestructive procedures (trans-scleral and endoscopic), and their combinations
  • Diurnal intraocular pressure (IOP) profiles and the impact of different treatments on IOP fluctuations in glaucoma eyes
  • The anatomical effects of surgery on the anterior segment structures in glaucoma eyes
  • Cost-effectiveness of glaucoma treatments

Cornea, External Eye Diseases & Refractive Surgery

  • Infectious keratitis: Risk factors, microbiological profile and treatment outcomes
  • Keratoconus: Diagnosis, monitoring of disease progression, novel management strategies​
  • Corneal transplantation: Lamella keratoplasty, osteo-odonto keratoprosthesis, allograft rejection and long-term outcomes
  • Dry eye syndrome: Diagnostics, customized approach for management, drug trials
  • Refractive surgery: Wound profile, the inflammatory cascades, long-term outcomes

Vitreo-Retinal Diseases and Management 

  • Development of novel techniques to improve multifocal electroretinography
  • Stereoscopic imaging of the fundus in patients with diabetic macular oedema
  • Fundus video amplification algorithms
  • The application of 3D printing in ophthalmology
  • Inherited retinal dystrophies and rehabilitation by a visual prosthesis
  • Efficacy and safety of medical therapy in neovascular age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PCV), myopic choroidal neovascularization (mCNV), retinal vein occlusion (RVO) and diabetic macular oedema (DMO)
  • Imaging and management of pathologic myopia
  • Clinical therapy of central serous chorioretinopathy
  • Ocular trauma

Orbital and Oculoplastic Surgery and Related Cell Biology

  • Clinical and translational research in thyroid associated orbitopathy (TAO)​
  • Surgical and investigative dacryology​
  • Endoscopic, image-guided and computer-assisted orbital surgeries
  • Clinical-pathological-radiological correlation of orbital disorders
  • 3D printing and 3D photography in orbital and oculoplastic surgeries
  • Mohs micrographic surgery
  • Orbital adipose tissue derived stromal/stem cells in health and diseases

Pediatric Ophthalmology & Strabismus, Childhood Myopia

  • Epidemiological study of children eye diseases in Hong Kong
  • Interventions in preventing myopia progression and its onset
  • Intermittent exotropia: the clinical course, new methods in evaluation of the control, effective surgical approaches, and prognostic factors of the surgical outcomes​
  • Retinoblastoma: the surgical outcome of different treatment strategies, and quality of life of retinoblastoma patients and their family

 

Investigative Research

​Glaucoma Investigation and Treatment, Ophthalmic Imaging, Optic Nerve Regeneration​

  • Optical coherence tomography imaging of the optic nerve head and retinal nerve fiber layer for early diagnosis and monitoring of glaucoma
  • Three-dimensional analysis of the anterior chamber angle for detection of angle closure diseases
  • Investigation of advanced laser and surgical techniques for lowering the intraocular pressure in the management of glaucoma
  • In vivo imaging of retinal ganglion cells to study optic nerve degeneration and regeneration ​

Retinal Vascular Imaging, Optical Coherence Tomography

  • Development and application of advanced image analysis techniques for studying eye diseases including diabetic retinopathy and glaucoma
  • Studying the role of vascular imaging markers in normal tension glaucoma
  • New vascular imaging subclinical makers for predicting diabetic retinopathy progression
  • Development of risk prediction algorithms based on imaging measures for stratifying patients into different risk categories
  • Retinal ganglion cell and microvascular network imaging in Alzheimer’s disease
  • Linking age-related eye disease and Alzheimer’s disease

 

Laboratory Research

Eye Genetics

  • Molecular genomics and gene mapping on primary open-angle glaucoma, primary angle-closure glaucoma, age-related macular degeneration, polypoidal choroidal vasculopathy, myopia, uveitis, diabetic retinopathy, retinitis pigmentosa, cataracts, and pediatric eye disorders including intermittent exotropia and accommodative esotropia
  • Molecular mechanisms and epi-genetics of glaucoma, macular diseases, high myopia, uveitis, retinoblastoma, Bietti crystalline dystrophy, Graves’ ophthalmopathy, diabetic retinopathy, retinitis pigmentosa, and cornea dystrophies
  • Whole genome studies, including genome-wide association studies and whole-exome sequencing studies on primary open-angle glaucoma, primary angle-closure glaucoma, age-related macular degeneration, polypoidal choroidal vasculopathy, and myopia
  • Genetic basis of quantitative ocular traits: intraocular pressure, axial length, corneal thickness, corneal curvature, anterior chamber depth, optic disc parameters, retinal nerve fiber layer thickness, and choroidal thickness
  • Genetics basis of progression of eye diseases (including glaucoma and myopia) and longitudinal change of ocular traits (including axial length, refraction, retinal nerve fiber layer, and choroidal thickness)
  • Gene-gene and gene-environment interactions in the mechanisms of major eye diseases, including glaucoma, age-related macular degeneration and myopia​

Gene Functions 

  • Studying gene functions in age-related macular degeneration, glaucoma and corneal diseases
  • The molecular pathogenesis and potential therapeutics of retinoblastoma
  • Quantitative proteomics of high myopia, age-related macular degeneration, diabetic macular oedema and retinal vein occlusion

Stem Cell Research 

  • Differentiation of human adult stem cells, such as periodontal ligament-derived stem cells, adipose tissue-derived stem cells and peripheral blood stem cells, into retinal and neuronal cells
  • The regulatory mechanisms of microRNAs in human adult stem cell differentiation
  • Retinal progenitor cell maintenance and differentiation by defined factors
  • Experimental studies for treatment of retinal diseases

Herbal Molecules

  • Biological and therapeutic effects of green tea extract, herbal molecules and GHRHR agonists/antagonists in eye diseases
  • Biological effects of novel anti-inflammatory agents
  • Autoimmune inflammation in eyes

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